Anti-fatigue activity of a triterpenoid-rich extract from Chinese bamboo shavings (Caulis bamfusae in taeniam)
Anti-fatigue activity of a triterpenoid-rich extract from Chinese bamboo shavings (Caulis bamfusae in taeniam)
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DOI：
10.1002/ptr.1965
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发表时间：
2006-10-01
影响因子：
7.2
通讯作者：
Zhang, Ying
中科院分区：
文献类型：
--
作者：
Zhang, Yu;Yao, Xiaobao;Zhang, Ying
研究了竹皮竹屑五环三萜提取物（EBS）对BALB/c小鼠的抗疲劳活性。分别以0.04（低剂量组）、0.08（中剂量组）和0.25 g/kg体重（高剂量组）的浓度给小鼠注射超临界CO2流体萃取（SFE）分离得到的EBS。通过体重变化、负重游泳试验、攀爬试验评估EBS的抗疲劳活性，并测定血清尿素氮、肝糖原、血乳酸等相应参数。结果表明，适当水平的EBS可延长BALB/c小鼠负重游泳和攀爬时间，并对血清尿素氮、肝糖原和血乳酸水平有积极影响，显著体现了EBS的抗疲劳活性。综上所述，预测EBS作为一种以五环三萜为主的组合物，其主要三萜成分具有抗疲劳活性，在相关领域具有很大的应用潜力。版权所有(c) 2006约翰威利父子有限公司
The anti-fatigue activity of a pentacyclic triterpenoid extract from bamboo shavings (EBS) from the bark of bamboo (Bambusa tuldoides Munro), was evaluated in BALB/c mice. EBS, isolated by the supercritical CO2 fluid extraction (SFE) technique, was given to mice at concentrations of 0.04 (low-dose group), 0.08 (middle-dose group) and 0.25 g/kg body weight (high-dose group). The anti-fatigue activity of EBS was estimated by the change in body weight, weight-loaded swimming test and climbing test, and corresponding parameters including serum urea nitrogen, hepatic glycogen and blood lactic acid were measured. The results showed that an appropriate level of EBS could prolong the weight-loaded swimming and climbing time, and had an active effect on the serum urea nitrogen, hepatic glycogen and blood lactic acid level in BALB/c mice, which significantly embodied the anti-fatigue activity of EBS. Overall, it is predicted that EBS, being a composition mainly containing a group of pentacyclic triterpenoids, and its main triterpenoid components have great potential for application in relevant fields for its anti-fatigue activity. Copyright (c) 2006 John Wiley & Sons, Ltd.