Pediatric blood pressures during anesthesia assessed using normalization and principal component analysis techniques.
Pediatric blood pressures during anesthesia assessed using normalization and principal component analysis techniques.
复制标题
使用归一化和主成分分析技术评估麻醉期间的小儿血压。
DOI：
10.1007/s10877-018-0199-z
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发表时间：
2019
影响因子：
2.2
通讯作者：
Cumin,David
中科院分区：
文献类型：
--
作者：
Harrison,MichaelJ;Connor,ChristopherW;Cumin,David
未麻醉和麻醉儿童的血压预期值都是已知的。麻醉过程中血压变化的统计可能具有重要的诊断意义，但尚未见报道。本研究的目的是报告四个接受心脏和非心脏手术的儿科年龄组血压变化的变化。使用麻醉期间儿科动脉内血压值的现有电子数据集，使用归一化和主成分分析技术对血压变化进行分析。心脏病和非心脏病病例分别进行分析。对于 1361 名非心脏病病例，平均收缩压从出生第一个月的 55.2 (17.6) mmHg 增加到 5-6 岁时的 85.4 (17.7) mmHg。对于 912 例心脏病病例，这些队列中的平均收缩压从 55.7 (16.7) 毫米汞柱增加到 71.8 (24.8) 毫米汞柱。对于第一个月内的非心脏病病例，30 秒内血压变化的平均值 (SD) 为 0.00 (8.8)，5-6 岁儿童为 0.0 (7.4)；对于心脏病病例，0.1 (9.2) 至 - 0.1 (9.2)。 5 分钟内收缩压的变化范围更大：非心脏疾病患者的收缩压变化范围为 0.1 (12.2) mmHg（第一个月）至 0.4 (11.5) mmHg（5-6 岁），心脏病患者的收缩压变化范围为 0.2 (12.5) 至 0.4 (14.2) mmHg。已经从人口数据库中分析了儿科心脏和非心脏手术病例的绝对血压和麻醉期间的血压变化。使用这些值，标准化和主成分分析的定量方法可以识别统计上显着的变化。
Expected values for blood pressure are known for both unanesthetized and anesthetized children. The statistics of changes in blood pressure during anesthesia, which may have important diagnostic significance, have not been reported. The purpose of this study was to report the variation in changes in blood pressure in four pediatric age groups, undergoing both cardiac and non-cardiac surgery. An analysis of the changes in blood pressure using normalization and principal component analysis techniques was performed using an existing electronic dataset of intra-arterial pediatric blood pressure values during anesthesia. Cardiac and noncardiac cases were analyzed separately. For 1361 non-cardiac cases, the average systolic blood pressure increased from 55.2 (17.6) mmHg in the first month of life to 85.4 (17.7) mmHg at 5–6 years. For 912 cardiac cases, the average systolic blood pressure increased from 55.7 (16.7) to 71.8 (24.8) mmHg in these cohorts. For non-cardiac cases in the first month, the mean (SD) for change in blood pressure over a 30 s period was 0.00 (8.8), for 5–6 year olds 0.0 (7.4); for cardiac cases, 0.1 (9.2) to − 0.1 (9.2). Variations in systolic blood pressure over a 5-min period were wider: in non-cardiac from 0.1 (12.2) mmHg (first month) to 0.4 (11.5) mmHg (5–6 year old) and from 0.2 (12.5) to 0.4 (14.2) mmHg in cardiac cases. Absolute blood pressures and changes in blood pressure during anesthesia in pediatric cardiac and non-cardiac surgical cases have been analyzed from a population database. Using these values, the quantitative methods of normalization and principal component analysis allow the identification of statistically significant changes.