Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
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环状RNA hsa_circ_0043280通过miR-203a-3p/PAQR3轴抑制宫颈癌肿瘤生长和转移
DOI：
10.1038/s41419-021-04193-7
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发表时间：
2021-09-29
影响因子：
9
通讯作者：
Yao S
中科院分区：
文献类型：
--
作者：
Zhang C;Liu P;Huang J;Liao Y;Pan C;Liu J;Du Q;Liu T;Shang C;Ooi S;Chen R;Xia M;Jiang H;Xu M;Zou Q;Zhou Y;Huang H;Pan Y;Yuan L;Wang W;Yao S
已知环状RNA（circRNA）在多种恶性肿瘤中充当关键调节因子。然而，circRNA在宫颈癌（CCa）中的作用在很大程度上仍然未知。在此，我们证明了来源于TADA 2A基因（hsa_circ_0043280）的circRNA在CCa中显著下调，并且这种表达的降低与不良预后相关。此外，我们的研究结果表明，hsa_circ_0043280作为一种肿瘤抑制剂，以抑制肿瘤的生长和转移的CCa。在机制上，hsa_circ_0043280竞争性地吸收miR-203 a-3 p并防止miR-203 a-3 p降低PAQR 3的水平。总的来说，我们的结果表明，hsa_circ_0043280在CCa的发展和转移中起着关键作用，因此表明hsa_circ_0043280具有作为CCa的预后生物标志物和治疗靶点的显著潜力。
Circular RNAs (circRNAs) are known to act as key regulators in a variety of malignancies. However, the role of circRNAs in cervical cancer (CCa) remains largely unknown. Herein, we demonstrated that a circRNA derived from theTADA2Agene (hsa_circ_0043280) was significantly downregulated in CCa and that this reduction in expression was correlated with a poor prognosis. Furthermore, our results demonstrated that hsa_circ_0043280 functions as a tumor suppressor to inhibit tumor growth and metastasis in CCa. Mechanistically, hsa_circ_0043280 competitively sponges miR-203a-3p and prevents miR-203a-3p from reducing the levels of PAQR3. Collectively, our results demonstrate that hsa_circ_0043280 plays a pivotal role in the development and metastasis of CCa, thus suggesting that hsa_circ_0043280 has significant potential as a prognostic biomarker and a therapeutic target for CCa.
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影响因子：
5.5
作者：
Guo Q;Ke XX;Fang SX;Gao WL;Song YX;Chen C;Lu HL;Xu G
通讯作者：
Xu G
DOI：
10.1186/s13046-016-0445-5
发表时间：
2016-10-28
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Liu TY;Chen J;Shang CL;Shen HW;Huang JM;Liang YC;Wang W;Zhao YH;Liu D;Shu M;Guo LY;Hu Z;Yao SZ
通讯作者：
Yao SZ
影响因子：
5.3
作者：
Shao, R;Bao, SD;Wang, XF
通讯作者：
Wang, XF
影响因子：
5.2
作者：
Tang, Qiu;Chen, Zhigang;Xu, Hai
通讯作者：
Xu, Hai
影响因子：
46.9
作者：
Jeck, William R.;Sharpless, Norman E.
通讯作者：
Sharpless, Norman E.