Enhancement of IgA production by membrane vesicles derived from Bifidobacterium longum subsp. infantis,
Enhancement of IgA production by membrane vesicles derived from Bifidobacterium longum subsp. infantis,
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源自长双歧杆菌亚种的膜囊泡增强 IgA 的产生。
DOI：
10.1093/bbb/zbac172
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Koichi Uegaki
中科院分区：
文献类型：
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作者：
Atsushi Kurata;Shino Yamasaki-Yashiki;Tomoya Imai;Ayano Miyazaki;Keito Watanabe;Koichi Uegaki
免疫球蛋白A(IgA)参与维持肠道内环境的稳定。虽然口服双歧杆菌可增加粪便中的IgA含量，但双歧杆菌对肠道免疫功能的影响尚不清楚。我们发现并鉴定了来自婴儿双歧杆菌长亚种宿主免疫细胞的膜泡(MVS)。婴儿双歧杆菌膜泡由细胞膜组成，并特异性地检测到胞外溶质结合蛋白(ESBP)。在某人面前。婴儿MV或重组ESBP、RAW264细胞产生促炎细胞因子IL-6。免疫球蛋白是在加入B后由Peyer‘s Patches细胞产生的。婴儿摩托。因此，ESBP OFB。婴儿巨噬细胞通过先天免疫细胞产生IL-6参与获得性免疫细胞产生IgA。
Immunoglobulin A (IgA) is involved in the maintenance of gut homeostasis. Although the oral administration of bifidobacteria increases the amount of fecal IgA, the effects of bifidobacteria on intestinal immunity remain unclear. We found and characterized membrane vesicles (MVs) derived fromBifidobacterium longumsubsp.infantistoward host immune cells.Bifidobacterium infantisMVs consisted of a cytoplasmic membrane, and extracellular solute-binding protein (ESBP) was specifically detected. In the presence ofB. infantisMVs or recombinant ESBP, RAW264 cells produced the pro-inflammatory cytokine IL-6. IgA was produced by Peyer's patches cells following the addition ofB. infantisMVs. Therefore, ESBP ofB. infantisMVs is involved in the production of IgA by acquired immune cells via the production of IL-6 by innate immune cells.