Fatigue and herpesvirus latency in women newly diagnosed with breast cancer
Fatigue and herpesvirus latency in women newly diagnosed with breast cancer
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DOI：
10.1016/j.bbi.2011.09.014
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发表时间：
2012-03-01
影响因子：
15.1
通讯作者：
Kiecolt-Glaser, Janice K.
中科院分区：
文献类型：
--
作者：
Fagundes, Christopher P.;Glaser, Ronald;Kiecolt-Glaser, Janice K.
疲劳是癌症幸存者的一个值得注意的临床问题，了解其病理生理学是重要的。目前的研究试图确定癌症治疗前存在的疲劳生物标志物。在158名新诊断为乳腺癌或等待阳性诊断结果的妇女中，研究了潜伏性EB病毒（EBV）和巨细胞病毒（CMV）表达与疲劳之间的关系。更高的CMV抗体滴度，而不是EBV抗体滴度，与疲劳的可能性更大。在控制饮酒、吸烟、合并症、抑郁症状、年龄、BMI、癌症分期和睡眠问题后，疲劳与较高的CMV抗体滴度之间的联系仍然存在。更多的睡眠问题和更高水平的抑郁症状也与更大的疲劳可能性有关。CMV抗体滴度，而不是EBV抗体滴度，与较高水平的C反应蛋白（CRP），但CRP与疲劳无关。当细胞免疫系统受损时，潜伏疱疹病毒的重新激活可能会引发慢性炎症反应。先前的工作表明，疲劳可能与炎症及其相关的疾病行为有关;因此，我们的研究结果可能会利用相同的生理基质。(C)2011 Elsevier Inc. All rights reserved.
Fatigue is a notable clinical problem in cancer survivors, and understanding its pathophysiology is important. The current study sought to determine biomarkers of fatigue that exist before cancer treatment. Relationships between the expression of latent Epstein-Barr virus (EBV) and cytomegalovirus (CMV) and fatigue were examined in 158 women newly diagnosed with breast cancer or awaiting a positive diagnostic result. Higher CMV antibody titers, but not EBV antibody titers, were associated with a greater likelihood of being fatigued. Associations between fatigue and higher CMV antibody titers remained after controlling for alcohol use, smoking, comorbidities, depressive symptoms, age, BMI, cancer stage, and sleep problems. More sleep problems and higher levels of depressive symptoms were also associated with a greater likelihood of being fatigued. CMV antibody titers, but not EBV antibody titers, were associated with higher levels of C-reactive protein (CRP), but CRP was not associated with fatigue. When the cellular immune system is compromised, reactivation of latent herpesviruses may fuel chronic inflammatory responses. Prior work has suggested that fatigue may be related to inflammation and its associated sickness behaviors; accordingly, our findings may be tapping into this same physiological substrate. (C) 2011 Elsevier Inc. All rights reserved.