Reporting Sex and Sex Differences in Preclinical Studies.
Reporting Sex and Sex Differences in Preclinical Studies.
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报告临床前研究中的性别和性别差异。
DOI：
10.1161/atvbaha.118.311717
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发表时间：
2018-10
期刊：
影响因子：
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通讯作者：
Daugherty A
中科院分区：
文献类型：
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作者：
Lu HS;Schmidt AM;Hegele RA;Mackman N;Rader DJ;Weber C;Daugherty A
e172动脉血栓血管生物学2018年10月和功能，血管生成和淋巴管生成。这些文章研究了斑马鱼在胚胎或幼虫发育阶段的性别无法确定。与哺乳动物相比，性别决定更为复杂，因为斑马鱼没有性染色体。339，340然而，有多种特征可以帮助识别成年阶段的雄性和雌性斑马鱼。由于在斑马鱼中发现了两性异形（在一些例子中341 -344），ATVB编辑鼓励作者研究两性，如果研究成年斑马鱼，则提供性别鉴定信息。如果在成年阶段之前无法确定性别，我们鼓励作者在方法部分简要说明这一潜在限制。
e172 Arterioscler Thromb Vasc Biol October 2018 and functions, angiogenesis, and lymphangiogenesis. These articles studied zebrafish at stages during embryonic or larval development when the sex cannot be identified. Sex determination is more complicated compared with mammalian organisms because zebrafish do not have sex chromosomes. 339,340 However, there are multiple features that can help identify male and female zebrafish at the adult stage. Because sexual dimorphism has been noted in zebrafish (in a few examples341–344), the ATVB editors encourage authors to study both sexes and provide the sex identification information if adult zebrafish are studied. If the sex cannot be identified before the adult stage, we encourage the authors to briefly state this potential limitation in the Methods section.