Silica mineralization on anisotropic gelatin-hydrogel scaffolds
Silica mineralization on anisotropic gelatin-hydrogel scaffolds
复制标题
各向异性明胶水凝胶支架上的二氧化硅矿化
DOI：
10.1039/d1ce01539g
复制
发表时间：
2022
期刊：
影响因子：
3.1
通讯作者：
Murai Kazuki
中科院分区：
文献类型：
--
作者：
Otsuka Kazuma;Murai Kazuki
我们研究了明胶水凝胶提供三维各向异性模板和支架的情况下二氧化硅矿化的机制。对于各向同性水凝胶，二氧化硅的形成仅在表面实现，但对于各向异性水凝胶，二氧化硅的形成也发生在内部。确定了二氧化硅矿化的两个阶段：开始时的反应期和二氧化硅生长停止并在水凝胶表面形成二氧化硅壳的时期。此外，与原始水凝胶相比，二氧化硅涂层水凝胶的储能模量和溶胶-凝胶相变温度有所增加。结果表明，无机壳抑制明胶的分子运动，从而稳定明胶网络。
We investigated the mechanisms of silica mineralization in the case where gelatin hydrogels provide a three-dimensional anisotropic template and scaffold. For isotropic hydrogels, silica formation was achieved only on the surface, but for anisotropic hydrogels it also occurred in the interior. Two stages of silica mineralization were identified: a reaction period at the beginning and a period when silica growth stops with the formation of a silica shell on the hydrogel surface. In addition, the silica-coated hydrogels exhibited increases in storage elastic modulus and sol–gel phase-transition temperature over pristine hydrogels. The results suggest that the inorganic shell inhibits the molecular motion of gelatin, and thus stabilizes the gelatin network.