Trained Immunity: An Overview and the Impact on COVID-19.
Trained Immunity: An Overview and the Impact on COVID-19.
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DOI：
10.3389/fimmu.2022.837524
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发表时间：
2022
影响因子：
7.3
通讯作者：
Moorman JP
中科院分区：
文献类型：
--
作者：
Brueggeman JM;Zhao J;Schank M;Yao ZQ;Moorman JP
有效治疗传染病通常需要采取多步骤方法来针对疾病发病机制中涉及的不同成分。同样，COVID-19 大流行已成为一场全球健康危机，需要全面了解严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 感染，以开发有效的治疗方法。增强先天免疫系统是增强对 COVID-19 免疫保护的一项潜在策略。这种增强被称为训练免疫，利用免疫系统调节剂来训练先天免疫细胞，使其在暴露于病原体后重新激活时产生增强的非特异性免疫反应，这一过程在 COVID-19 大流行之前已在体外和体内临床研究中进行了研究。对诱导保护性训练免疫至关重要的基本途径的评估将为识别可能缓解 COVID-19 危机的潜在治疗靶点提供见解。在这里，我们回顾了多种免疫训练剂，包括卡介苗（BCG）、β-葡聚糖和脂多糖（LPS），以及参与训练免疫的两种最流行的细胞类型，单核细胞和自然杀伤（NK）细胞，并比较了先天免疫中涉及的信号通路。此外，我们还讨论了经过训练的 COVID-19 免疫临床试验，强调经过训练的免疫对抗 SARS-CoV-2 感染的潜力。了解训练剂激活先天免疫细胞以重新编程免疫反应的机制可能有助于开发针对 COVID-19 的预防和治疗目标。
Effectively treating infectious diseases often requires a multi-step approach to target different components involved in disease pathogenesis. Similarly, the COVID-19 pandemic has become a global health crisis that requires a comprehensive understanding of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infection to develop effective therapeutics. One potential strategy to instill greater immune protection against COVID-19 is boosting the innate immune system. This boosting, termed trained immunity, employs immune system modulators to train innate immune cells to produce an enhanced, non-specific immune response upon reactivation following exposure to pathogens, a process that has been studied in the context of in vitro and in vivo clinical studies prior to the COVID-19 pandemic. Evaluation of the underlying pathways that are essential to inducing protective trained immunity will provide insight into identifying potential therapeutic targets that may alleviate the COVID-19 crisis. Here we review multiple immune training agents, including Bacillus Calmette-Guérin (BCG), β-glucan, and lipopolysaccharide (LPS), and the two most popular cell types involved in trained immunity, monocytes and natural killer (NK) cells, and compare the signaling pathways involved in innate immunity. Additionally, we discuss COVID-19 trained immunity clinical trials, emphasizing the potential of trained immunity to fight SARS-CoV-2 infection. Understanding the mechanisms by which training agents activate innate immune cells to reprogram immune responses may prove beneficial in developing preventive and therapeutic targets against COVID-19.
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DOI：
10.1056/nejmoa2109072
发表时间：
2021-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bergwerk M;Gonen T;Lustig Y;Amit S;Lipsitch M;Cohen C;Mandelboim M;Levin EG;Rubin C;Indenbaum V;Tal I;Zavitan M;Zuckerman N;Bar-Chaim A;Kreiss Y;Regev-Yochay G
通讯作者：
Regev-Yochay G
影响因子：
5.5
作者：
Arts, Rob J. W.;Blok, Bastiaan A.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
64.5
作者：
Bekkering, Siroon;Arts, Rob J. W.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
29
作者：
Arts RJ;Novakovic B;Ter Horst R;Carvalho A;Bekkering S;Lachmandas E;Rodrigues F;Silvestre R;Cheng SC;Wang SY;Habibi E;Gonçalves LG;Mesquita I;Cunha C;van Laarhoven A;van de Veerdonk FL;Williams DL;van der Meer JW;Logie C;O'Neill LA;Dinarello CA;Riksen NP;van Crevel R;Clish C;Notebaart RA;Joosten LA;Stunnenberg HG;Xavier RJ;Netea MG
通讯作者：
Netea MG
DOI：
10.1161/atvbaha.114.303887
发表时间：
2014-08-01
影响因子：
8.7
作者：
Bekkering, Siroon;Quintin, Jessica;Riksen, Niels P.
通讯作者：
Riksen, Niels P.