Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris
Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris
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Alstonlarsines A-D，来自 Alstonia brothers 的四种重排吲哚生物碱
DOI：
10.1021/acs.orglett.9b00230
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Yue Jian Min
中科院分区：
文献类型：
--
作者：
Zhu Xu Xin;Fan Yao Yue;Xu Lei;Liu Qun Fang;Wu Jiang Ping;Li Jing Ya;Li Jia;Gao Kun;Yue Jian Min
本文报道了从植物灯台树（AlstoniacomnisL.）中分离得到的4种吲哚生物碱，分别命名为灯台树larsinesA-D（1-4），并对其结构进行了表征。化合物1具有笼状9-氮杂三环[4.3.1.03，8]癸烷基序的新碳骨架，化合物2 - 4具有首次在自然界中发现的罕见碳骨架。提出了1 - 4的合理生物合成途径。化合物1显示DRAK 2抑制活性，IC 50值为11.65 ± 0.63 μ M。
Four indole alkaloids, alstonlarsines A–D (1–4), were isolated fromAlstonia scholarisand structurally characterized. Compound1possesses a new carbon skeleton with a cage-shaped 9-azatricyclo[4.3.1.03,8]decane motif, and compounds2–4feature a rare carbon skeleton that was found in nature for the first time. Plausible biosynthetic routes for1–4are proposed. Compound1showed DRAK2 inhibitory activity with an IC50value of 11.65 ± 0.63 μΜ.