Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130
Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130
复制标题
癌胎儿 miR-17-5p 表达升高通过抑制其靶基因 P130 调节结直肠癌进展
DOI：
10.1038/ncomms2276
复制
发表时间：
2012-12-01
影响因子：
16.6
通讯作者：
Qin, Huanlong
中科院分区：
文献类型：
--
作者：
Ma, Yanlei;Zhang, Peng;Qin, Huanlong
MicroRNAs(MiRNAs)对于调节正常的胚胎发育和癌症的发生是必不可少的。在这里，我们报告miR-17-5p，一个癌胎儿miRNA，是结直肠癌进展的关键调节因子。我们证明miR-17-5p是一种致癌的miRNA，通过靶向编码P130的基因并随后激活Wnt/β-catenin途径来调节肿瘤的发生和发展。使用来自两个大型结直肠癌患者队列的样本，我们发现，与miRNA低表达的患者相比，miR-17-5p高表达的肿瘤患者的总体存活率较短，但对辅助化疗的反应更好。我们还观察到miR-17-5p和P130的表达之间存在很强的负相关。目前的发现表明miR-17-5p是结直肠癌进展的关键决定因素。
MicroRNAs (miRNAs) are essential for regulating normal embryonic development and carcinogenesis. Here we report that miR-17-5p, an oncofoetal miRNA, is a key regulator of colorectal cancer progression. We show that miR-17-5p is an oncogenic miRNA that regulates tumorigenesis and progression by targeting the gene encoding P130 and subsequently activating the Wnt/β-catenin pathway. Using specimens from two large cohorts of colorectal cancer patients, we found that patients whose tumours had high miR-17-5p expression had shorter overall survival rates but showed a better response to adjuvant chemotherapy than did patients whose tumours had low miRNA expression. We also observed a strong inverse correlation between miR-17-5p and P130 expression. The current findings suggest that miR-17-5p is a crucial determinant of colorectal cancer progression.