Exploring the significance of morphological diversity for cerebellar granule cell excitability.
Exploring the significance of morphological diversity for cerebellar granule cell excitability.
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DOI：
10.1038/srep46147
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发表时间：
2017-04-13
影响因子：
4.6
通讯作者：
Brickley SG
中科院分区：
文献类型：
--
作者：
Houston CM;Diamanti E;Diamantaki M;Kutsarova E;Cook A;Sultan F;Brickley SG
小脑颗粒细胞（CGC）相对简单紧凑的形态导致CGC形状的异质性对苔藓纤维（MF）信息整合的影响可以忽略不计。在电生理记录之后，利用高分辨率成像数据构建3D模型，以确定可能影响成人cgc编码MF输入模式的形态学特征。MF和CGC形态的定量分析提供了证据，表明CGC可能与单个MF输入产生的多个莲座相连接。我们计算模型的预测表明，MF输入在CGC层中的编码密度可能比以前的模型所显示的要高。此外，到达最靠近轴突的树突的MF信号将产生更大的CGC激发。然而，这种形态变异对MF输入选择性的影响将通过高水平的CGC抑制而减弱，从而为MF→CGC途径提供进一步的灵活性。当考虑到单个cgc的多模态中频感觉输入的整合时，这些特征可能特别重要。
The relatively simple and compact morphology of cerebellar granule cells (CGCs) has led to the view that heterogeneity in CGC shape has negligible impact upon the integration of mossy fibre (MF) information. Following electrophysiological recording, 3D models were constructed from high-resolution imaging data to identify morphological features that could influence the coding of MF input patterns by adult CGCs. Quantification of MF and CGC morphology provided evidence that CGCs could be connected to the multiple rosettes that arise from a single MF input. Predictions from our computational models propose that MF inputs could be more densely encoded within the CGC layer than previous models suggest. Moreover, those MF signals arriving onto the dendrite closest to the axon will generate greater CGC excitation. However, the impact of this morphological variability on MF input selectivity will be attenuated by high levels of CGC inhibition providing further flexibility to the MF → CGC pathway. These features could be particularly important when considering the integration of multimodal MF sensory input by individual CGCs.