Is maternal alcohol use a risk factor for early-onset sepsis in premature newborns?
Is maternal alcohol use a risk factor for early-onset sepsis in premature newborns?
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DOI：
10.1016/j.alcohol.2004.06.003
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发表时间：
2004-06-01
期刊：
影响因子：
2.3
通讯作者：
Brown, LAS
中科院分区：
文献类型：
--
作者：
Gauthier, TW;Manar, MH;Brown, LAS
由于慢性酒精滥用会改变成年人的免疫防御系统并增加感染，我们检验了一种假设，即怀孕期间母亲饮酒会增加极低出生体重(VLBW)早产儿败血症的风险。我们对出生在格雷迪纪念医院(佐治亚州亚特兰大)的极低出生体重儿进行了病例对照分析。酒精暴露作为预测变量，通过母亲自我报告进行评估。结果变量为早发性和多发性迟发性脓毒症。采用Fisher精确检验进行单因素分析，采用二元Logistic回归进行多因素分析。酒精暴露组(n=20)的早发性脓毒症是匹配对照组(n=168)的15倍[酒精暴露组，10%，与对照组，0.6%：优势比(OR)6.8(95%可信区间[CI]，2.7-17.1)，P<或等于.051]。酒精+可卡因暴露组(n=)的早发性脓毒症与对照组的结果没有不同。多发性迟发性脓毒症的患病率在暴露组之间没有差异。控制绒毛膜羊膜炎和胎膜早破的Logistic回归分析显示，酒精暴露增加了早发性败血症的独立风险[OR16(95%CI，1.2-210)，P<0.05]。我们得出结论，在这组极低出生体重儿中，酒精暴露显著增加了早发性败血症的风险。妊娠期间母体酗酒对极低出生体重儿感染风险的影响需要进一步分析。(C)2004 Elsevier Inc.保留所有权利。
Because chronic alcohol abuse alters immune defenses and increases infection in adults, we tested the hypothesis that maternal alcohol use during pregnancy would increase the risk of sepsis in very low birth weight (VLBW) premature newborns. We performed a case-controlled analysis of VLBW newborns born at Grady Memorial Hospital (Atlanta, GA). Alcohol exposure, as the predictive variable, was assessed by maternal self-report. The outcome variables were early-onset and multiple late-onset sepsis. Univariate analysis with Fisher exact test and multivariate analysis with the use of binary logistic regression were performed. Early-onset sepsis was 15-fold higher in the alcohol-exposed group (n = 20) compared with findings for the matched control group (n = 168) [alcohol -exposed group, 10%, vs. control group, 0.6%: odds ratio (OR) 6.8 (95% confidence interval [CI], 2.7-17.1), P less than or equal to.051. Early-onset sepsis in the alcohol + cocaine-exposed group (n = 64) did not differ from findings for the control group. The prevalence of multiple late-onset sepsis did not differ among the exposure groups. Logistic regression analysis, controlling for chorioamnionitis and premature prolonged rupture of membranes, demonstrated an independent, increased risk of early-onset sepsis with alcohol exposure [OR 16 (95% CI, 1.2-210), P less than or equal to.05]. We conclude that alcohol exposure significantly increased the risk of early-onset sepsis in this group of VLBW newborns. The effects of matemal alcohol abuse during pregnancy on the risk of infection in the VLBW newbom require further analysis. (C) 2004 Elsevier Inc. All rights reserved.