Receptors and transmission in the brain-gut axis: Potential for novel therapies - I. Receptors on visceral afferents
Receptors and transmission in the brain-gut axis: Potential for novel therapies - I. Receptors on visceral afferents
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DOI：
10.1152/ajpgi.2001.280.5.g787
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发表时间：
2001-05-01
影响因子：
4.5
通讯作者：
Grundy, D
中科院分区：
文献类型：
--
作者：
Kirkup, AJ;Brunsden, AM;Grundy, D
内脏传入是从肠道到中枢神经系统的信息高速公路。这些感觉神经表达广泛的膜受体，可以调节它们的敏感性。在这篇主题文章中，我们集中讨论那些增强内脏传入神经元兴奋性的受体。一些受体是参与感觉信号传导的模态特异性转导途径的一部分。在缺血、损伤或炎症过程中，由来自多种细胞来源的物质激活的其他物质以协同方式起作用，引起传入神经对机械和化学刺激的急性或慢性敏化。这种超敏反应是肠易激综合征等疾病的标志。因此，这些受体代表了药物治疗的合理靶点，目的是减弱不适当的内脏感觉和异常的反射活动，这是肠功能改变的基础。
Visceral afferents are the information superhighway from the gut to the central nervous system. These sensory nerves express a wide range of membrane receptors that can modulate their sensitivity. In this themes article, we concentrate on those receptors that enhance the excitability of visceral afferent neurons. Some receptors are part of a modality-specific transduction pathway involved in sensory signaling. Others, which are activated by substances derived from multiple cellular sources during ischemia, injury, or inflammation, act in a synergistic fashion to cause acute or chronic sensitization of the afferent nerves to mechanical and chemical stimuli. Such hypersensitivity is the hallmark of conditions such as irritable bowel syndrome. Accordingly, these receptors represent a rational target for drug treatments aimed at attenuating both the inappropriate visceral sensation and the aberrant reflex activity that are the foundation for alterations in bowel function.