Review of recent evidence of toxic effects of hexachlorophene.
Review of recent evidence of toxic effects of hexachlorophene.
复制标题
审查六氯酚毒性作用的最新证据。
DOI：
10.1542/peds.51.2.391
复制
发表时间：
1973
期刊：
影响因子：
8
通讯作者：
R. Kimbrough
中科院分区：
文献类型：
--
作者：
R. Kimbrough
讨论了已发表的关于六氯苯对动物和人的毒性的数据。在作者的实验室中进行的研究，包括动物和人的六氯苯血液水平的测定，也被综述。六氯苯可以使大鼠、兔子、猫和猪瘫痪，并使绵羊失明。对反复服用六氯苯的大鼠和猴子的大脑进行显微镜检查，发现白质和正常灰质处于海绵状状态。少量的六氯苯会通过动物和人的皮肤吸收。除了六氯苯对神经系统的影响外，这种化学物质还会解偶联可能导致体温升高的氧化磷酸化。
The published data on the toxicity of hexachlorophene in animals and man are discussed. Studies performed in the author's laboratory including hexachlorophene blood level determinations in animals and man are also reviewed. Hexachlorophene can produce paralysis in rats, rabbits, cats, and pigs and blindness in sheep. Microscopic examination of the brains of rats and monkeys given repeated doses of hexachlorophene shows status spongiosus of the white matter and normal gray matter. Small amounts of hexachlorophene are absorbed through the skin of animals as well as man. Aside from the neurological effects of hexachlorophene, the chemical uncouples oxidative phosphorylation which may cause body temperature elevation.