Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults
Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults
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DOI：
10.1038/oby.2006.248
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发表时间：
2006-12-01
期刊：
影响因子：
6.9
通讯作者：
DeSouza, Christopher A.
中科院分区：
文献类型：
--
作者：
Van Guilder, Gary P.;Hoetzer, Greta L.;DeSouza, Christopher A.
目的：肥胖和代谢综合征(METS)都独立地与氧化应激和炎症应激增加有关。这项研究验证了这样一种假设，即与单纯肥胖相比，患有蛋氨酸的肥胖与更大的氧化和炎症负担有关。研究方法和程序：研究对象为48名正常体重和40名肥胖者(20名没有蛋氨酸，20名患有蛋氨酸)。METS的定义是根据国家胆固醇教育计划成人治疗小组III标准。用酶免疫法测定血浆氧化低密度脂蛋白、C反应蛋白、肿瘤坏死因子-a、白介素6和白介素18浓度。结果：正常体重对照组血浆氧化应激和炎症标志物水平最低。值得注意的是，成年肥胖者血浆氧化型低密度脂蛋白(62.3+/-3.2vs.54.0+/-4.0U/L；p<；0.05)、C反应蛋白(3.0+/-0.6vs.1.5+/-0.3 mg/L；p<；0.01)、肿瘤坏死因子-a(2.1+/-0.1vs.1.6+/-0.1pg/mL；p<；IL-6(2.8+/-0.4vs.1.4+/-0.2pg/m L；p<；0.01)和IL-18(253+/-16vs.199+/-16pg/m l；p<；0.01)。氧化和炎症应激增加可能导致患有METS的肥胖成年人患冠心病和脑血管疾病的风险更大。
Objective: Both obesity and the metabolic syndrome (MetS) have been independently linked with increased oxidative and inflammatory stress. This study tested the hypothesis that obesity with MetS is associated with greater oxidative and inflammatory burden compared with obesity alone.Research Methods and Procedures: Forty-eight normal-weight and 40 obese (20 without MetS; 20 with MetS) adults were studied. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria. Plasma concentrations of oxidized low-density lipoprotein, C-reactive protein, tumor necrosis factor-a, interleukin (IL)-6, and IL-18 were determined by enzyme immunoassay.Results: Plasma biomarkers of oxidative stress and inflammation were lowest in normal-weight controls. Of note, obese MetS adults demonstrated significantly higher plasma concentrations of oxidized low-density lipoprotein (62.3 +/- 3.2 vs. 54.0 +/- 4.0 U/L; p < 0.05), C-reactive protein (3.0 +/- 0.6 vs. 1.5 +/- 0.3 mg/L; p < 0.01), tumor necrosis factor-a (2.1 +/- 0.1 vs. 1.6 +/- 0.1 pg/mL; p < 0.05), IL-6 (2.8 +/- 0.4 vs. 1.4 +/- 0.2 pg/mL; p < 0.01), and IL-18 (253 +/- 16 vs. 199 +/- 16 pg/mL; p < 0.01), compared with obese adults without MetS.Discussion: These results suggest that MetS heightens oxidative stress and inflammatory burden in obese adults. Increased oxidative and inflammatory stress may contribute to the greater risk of coronary heart disease and cerebrovascular disease in obese adults with MetS.