Prenatal disturbance alters the size of the corpus callosum in young monkeys
Prenatal disturbance alters the size of the corpus callosum in young monkeys
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DOI：
10.1002/dev.10063
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发表时间：
2002-09-01
影响因子：
2.2
通讯作者：
Schneider, ML
中科院分区：
文献类型：
--
作者：
Coe, CL;Lulbach, GR;Schneider, ML
许多因素在胎儿生命和婴儿早期已被发现影响大脑的发育。下面的研究调查了怀孕期间母亲的压力是否会影响婴儿猴子大脑中一个敏感区域-胼胝体的大小和形状。对于30%的妊娠期，从受孕后第90天至第140天，每天使用声惊吓方案干扰妊娠雌性动物10分钟。然后利用磁共振成像对婴儿的大脑进行矢状和冠状扫描。胼胝体的形态测量进行了比较，在16只猴子（5个控制和I I干扰怀孕）。产前条件改变胼胝体，但在一个差异的方式为男性和女性的猴子。根据正中矢状面和旁矢状面扫描，产前干扰的男性后代显示胼胝体的整体大小减少，而产前干扰导致女性的面积增加。从冠状面图像对胼胝体高度的评估表明，体积变化与从后枕骨到压部的前后形状的变化有关。这些发现与其他动物和人类的观察结果一致，这些观察结果表明，产前和产后因素会影响胼胝体的发育，可能会影响两半球之间的沟通。(C)2002 Wiley Periodicals，Inc.
Many factors during fetal life and early infancy have been found to affect the development of the brain. The following study investigated whether maternal stress during pregnancy would influence the size and shape of one sensitive brain region, the corpus callosum, in infant monkeys. For 30% of the gestation period, from Days 90 to 140 postconception, gravid females were disturbed using an acoustical startle protocol for 10 min per day. Magnetic resonance imaging was then employed to obtain sagittal and coronal scans of their infants' brains. Morphometric measures of the corpus callosum were compared in 16 monkeys (5 controls and I I from disturbed pregnancies). Prenatal conditions altered the corpus callosum, but in a differential manner for male and female monkeys. Based on the midsagittal and parasagittal scans, prenatally disturbed male offspring showed a decrease in overall size of the corpus callosum whereas the prenatal disturbance resulted in an increased area in females. An evaluation of callosal height from the coronal images suggested that the volumetric change was associated with a shift in anterior-to-posterior shape from the genu back toward the splenium. These findings concur with observations in other animals and humans, which have indicated that prenatal and postnatal factors can influence the development of the corpus callosum, possibly affecting communication between the hemispheres. (C) 2002 Wiley Periodicals, Inc.