A Novel Prins Cyclization through Benzylic/Allylic C-H Activation
A Novel Prins Cyclization through Benzylic/Allylic C-H Activation
复制标题
通过苯甲基/烯丙基 C-H 激活的新型原基环化
DOI：
10.1021/ol901291w
复制
发表时间：
2009-08-06
期刊：
影响因子：
5.2
通讯作者：
She, Xuegong
中科院分区：
文献类型：
--
作者：
Yu, Binxun;Jiang, Tuo;She, Xuegong
A step-economic method to construct the tetrahydropyran ring, involving sequential benzylic/allylic C-H bond activation via DDQ oxidation and nucleophilic attack of an unactivated olefin, is described. The equatorial-trisubstituted Prins products are obtained from benzyl and allyl homoallylic ethers with high yield and stereochemical fidelity.
