Convenient synthesis of 6-alkyl phenanthridines and 1-alkyl isoquinolines via silver-catalyzed oxidative radical decarboxylation
Convenient synthesis of 6-alkyl phenanthridines and 1-alkyl isoquinolines via silver-catalyzed oxidative radical decarboxylation
复制标题
通过银催化氧化自由基脱羧方便合成6-烷基菲啶和1-烷基异喹啉
DOI：
10.1039/c6ob02331b
复制
发表时间：
2017
影响因子：
3.2
通讯作者：
Li Ming
中科院分区：
文献类型：
--
作者：
Yao Qian;Zhou Xin;Zhang Xiuli;Wang Cong;Wang Peng;Li Ming
A convenient and efficient protocol for the synthesis of 6-alkyl phenanthridines and 1-alkyl isoquinolines has been developed. The reaction relies on the coupling of 2-isocyanobiphenyls and vinyl isonitriles with alkyl radicals formed by the silver-catalyzed decarboxylation of stoichiometric aliphatic carboxylic acids, and affords diverse phenanthridine and isoquinoline derivatives under mild reaction conditions. The experiment of β-scission of cyclobutylcarbinyl radicals is used to shed light on the reaction mechanism.
