Accelerated Micellization and Aggregation of Pluronic Micelles by Interaction with Heparin
Accelerated Micellization and Aggregation of Pluronic Micelles by Interaction with Heparin
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DOI：
10.1163/156856209x436447
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Kim, Young Ha
中科院分区：
文献类型：
--
作者：
Lee, Seung-Young;Tae, Giyoong;Kim, Young Ha
研究了肝素与Pluronic共聚物这两种重要的生物医用大分子之间的吸引作用对Pluronic共聚物胶束状态的影响。肝素的加入使Pluronic溶液的临界胶束化温度（CMT）降低，表明肝素促进了胶束化。此外，Pluronic胶束通过肝素的作用而缔合，并且聚集程度随着肝素量的增加而变得更加显著。肝素在Pluronic胶束间的缔合作用增强了双丙烯酸酯化Pluronic溶液的光聚合化学交联和胶束堆积的物理凝胶化效率。因此，肝素除了其生物学功能外，还可以作为Pluronic胶束的敏感调节剂。(C)Koninklijke Brill NV，莱顿，2010年
The effect of attractive interaction between heparin and Pluronic co-polymer, two important macromolecules in biomedical applications, on the micellar state of Pluronic co-polymer was characterized. By the addition of heparin, the critical micellization temperature (CMT) of Pluronic solution decreased, indicating that heparin promoted micellization. Also, the Pluronic micelles were associated by the action of heparin, and the degree of aggregation became more pronounced by increasing the heparin amount. The association among Pluronic micelles by heparin enhanced the efficiency of chemical cross-linking of di-acrylated Pluronic solution by photo-polymerization, as well as the physical gelation by micelle packing. Thus, heparin can act as a sensitive modulator of Pluronic micelles in addition to its biological functions. (C) Koninklijke Brill NV, Leiden, 2010