Gender Difference in Arterial Stiffness in a Multicenter Cross-Sectional Study: The Korean Arterial Aging Study (KAAS)
Gender Difference in Arterial Stiffness in a Multicenter Cross-Sectional Study: The Korean Arterial Aging Study (KAAS)
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DOI：
10.1159/000365267
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Chung, Namsik
中科院分区：
文献类型：
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作者：
Kim, Jang-Young;Park, Jeong Bae;Chung, Namsik
动脉僵硬增加已成为男性和女性未来心血管(CV)事件的重要危险因素。然而，与性别相关的动脉僵硬的差异还没有得到明确的证明。因此，我们确定性别是否影响有和没有心血管危险因素的受试者的动脉僵硬。我们连续招募了1,588名年龄在17-87岁(平均年龄：46.5岁；51%为女性)的韩国动脉老化研究(KAAS)的受试者，该研究是一项来自韩国13所大学医院的多中心登记，用于评估动脉僵硬。我们比较了无危险因素的健康男性和女性与那些有吸烟习惯、高血压、糖尿病和血脂异常但未接受药物治疗的高危受试者的动脉硬化指标--中枢增强指数(AIX)、主动脉脉搏波速度(PWV)和脉压(PP)放大。男性主动脉PWV和PP扩大率显著高于女性(7.78±1.16vs.7.64±1.15m/S，p=0.015；1.39±0.22vs.1.30+/-0.18，p<；0.001)。然而，女性的中枢性AIX显著高于男性(23.5+/-11.9vs.16.1+/-12.6%，p<；0.001)。无论男性还是女性，高危组的中心AIX和主动脉PWV值均显著高于健康组。在男性中，中心AIX和主动脉PWV与年龄和血压呈正相关，与体重指数呈负相关。在女性中，中心AIX与年龄、舒张压和血清胆固醇水平呈正相关。主动脉PWV与年龄、收缩压、空腹血糖、心率呈正相关。无论男女，PP扩增与年龄、血压呈负相关，与心率呈正相关。总而言之，动脉僵硬主要由性别、年龄和血压决定。动脉僵硬的标志在男性和女性之间有所不同。仅在女性中，血脂异常和血糖导致动脉僵硬程度略有增加。因此，女性的动脉可能比男性更容易受到心血管危险因素的影响。(C)2014年S.Karger AG，巴塞尔
Elevated arterial stiffness has emerged as an important risk factor for future cardiovascular (CV) events in men and women. However, gender-related differences in arterial stiffness have not been clearly demonstrated. We thus determine whether gender affects arterial stiffness in subjects with and without CV risk factors. We consecutively enrolled 1,588 subjects aged 17-87 years (mean age: 46.5; 51% women) from the Korean Arterial Aging Study (KAAS), which is a multicenter registry from 13 university hospitals in Korea for the evaluation of arterial stiffness. We compared markers of arterial stiffness-central augmentation index (AIx), aortic pulse wave velocity (PWV), and pulse pressure (PP) amplification-in apparently healthy men and women without risk factors with those in high-risk subjects with a smoking habit, hypertension, diabetes, and dyslipidemia but without drug treatment. Aortic PWV and PP amplification were significantly higher in men than in women (7.78 +/- 1.16 vs. 7.64 +/- 1.15 m/s, p = 0.015, and 1.39 +/- 0.22 vs. 1.30 +/- 0.18, p < 0.001, respectively). However, women had a significantly higher central AIx than men (23.5 +/- 11.9 vs. 16.1 +/- 12.6%, p < 0.001). The central AIx and aortic PWV values were significantly higher in the high-risk group than in the healthy group for both men and women. In men, central AIx and aortic PWV were associated positively with age and blood pressure, and negatively with body mass index. In women, central AIx was positively related to age, diastolic blood pressure, and serum cholesterol levels. Aortic PWV was positively related to age, systolic blood pressure, fasting glucose, and heart rate. PP amplification was associated negatively with age and blood pressure and positively with heart rate in both men and women. In conclusion, arterial stiffness is mainly determined by sex, age, and blood pressure. Markers of arterial stiffness differ between men and women. Dyslipidemia and glucose contribute to a modest increase in arterial stiffness only in women. Therefore, the arteries of women may be more vulnerable to CV risk factors than those of men. (C) 2014 S. Karger AG, Basel