Blood pressure and site-specific cancer mortality: evidence from the original Whitehall study
Blood pressure and site-specific cancer mortality: evidence from the original Whitehall study
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DOI：
10.1038/sj.bjc.6601255
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发表时间：
2003-10-06
影响因子：
8.8
通讯作者：
Smith, GD
中科院分区：
文献类型：
--
作者：
Batty, GD;Shipley, MJ;Smith, GD
有关血压与癌症风险的研究有一些缺点，并揭示了不一致的结果。在17498名中年伦敦政府雇员中，我们将基线检查（1967-1970）时记录的收缩压和舒张压与25年后13个解剖部位的癌症死亡风险相关。在调整潜在的混杂和介导因素后，血压与白血病和胰腺癌（仅舒张期）死亡率呈负相关。血压也与肝癌和直肠癌呈正相关（仅舒张压）。在这项提供高功效的大规模前瞻性研究中，血压与癌症之间的统计学显著性相关性很少，并且其程度足够小，可以归因于偶然性或混杂因素。
Studies relating blood pressure to cancer risk have some shortcomings and have revealed inconsistent findings. In 17 498 middle-aged London-based government employees we related systolic and diastolic blood pressure recorded at baseline examination (1967-1970) to the risk of cancer mortality risk at 13 anatomical sites 25 years later. Following adjustment for potential confounding and mediating factors, inverse associations between blood pressure and mortality due to leukaemia and cancer of the pancreas (diastolic only) were seen. Blood pressure was also positively related to cancer of the liver and rectum (diastolic only). The statistically significant blood pressure-cancer associations seen in this large-scale prospective investigation offering high power were scarce and of sufficiently small magnitude as to be attributable to chance or confounding.