Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus
Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus
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DOI：
10.1152/ajpendo.00210.2009
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发表时间：
2009-07-01
影响因子：
5.1
通讯作者：
Holloszy, John O.
中科院分区：
文献类型：
--
作者：
Kirwan, John P.;Solomon, Thomas P. J.;Holloszy, John O.
Kirwan JP，所罗门TP，Wojta DM，Staten MA，Holloszy JO. 7天运动训练对2型糖尿病胰岛素敏感性和反应性的影响。Am J Physiol Endocrinol Metab 297：E151-E156，2009.首次发表于2009年4月21日; doi：10.1152/ajpendo.00210.2009.-本研究的目的是确定1）2型糖尿病患者短期运动训练诱导的胰岛素作用改善是否是由于胰岛素敏感性改善、胰岛素反应性改善或胰岛素敏感性和反应性改善的组合，以及2）短期运动训练是否改善了胰岛素对肝脏葡萄糖产生的抑制。14例肥胖的2型糖尿病患者，年龄64 ± 2岁，接受了两阶段高胰岛素正葡萄糖钳夹术，第一阶段40 mU.m（-2）.min（-1）胰岛素输注，第二阶段1，000 mU.m（-2）.min（-1）胰岛素输注，同时在7天运动前后输注[3-H-3]葡萄糖。训练包括30分钟的自行车和30分钟的跑步机步行，每天近似70%的最大有氧能力，持续7天。在没有体重减轻的情况下，运动计划导致胰岛素作用的改善。在训练后的两个高胰岛素血症阶段，正葡萄糖钳夹期间的葡萄糖处置率显著增加（40 mU：1.84 +/- 0.32至2.67 +/- 0.37 mg.kg（-1）.min（-1），P < 0.0001; 1，000 mU：7.57 +/- 0.61至8.84 +/- 0.56 mg.kg（-1）.mi（n-）1，P = 0.008）。基础状态（3.17 +/- 0.43 vs. 2.54 +/- 0.26 mg.kg（-1）min（-1），P = 0.05）和40 mU钳夹阶段（1.15 +/- 0.41 vs. 0.46 +/- 0.20 mg.kg（-1）.min（-1），P = 0.03）的肝脏葡萄糖生成量在训练后显著降低。一周的剧烈运动训练可以显著改善2型糖尿病患者的胰岛素作用。这些改善包括外周胰岛素敏感性和反应性增加以及对肝脏葡萄糖产生的抑制增强。
Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO. Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 297: E151-E156, 2009. First published April 21, 2009; doi: 10.1152/ajpendo.00210.2009.-The objectives of this study were to determine whether 1) the improvement in insulin action induced by short-term exercise training in patients with type 2 diabetes is due to an improvement in insulin sensitivity, an improvement in insulin responsiveness, or a combination of improved insulin sensitivity and responsiveness and 2) short-term exercise training results in improved suppression of hepatic glucose production by insulin. Fourteen obese patients with type 2 diabetes, age 64 +/- 2 yr, underwent a two-stage hyperinsulinemic euglycemic clamp procedure, first stage 40 mU.m(-2).min(-1) insulin infusion, second stage 1,000 mU.m(-2).min(-1) insulin infusion, together with a [3-H-3] glucose infusion, before and after 7 days of exercise. The training consisted of 30 min of cycling and 30 min of treadmill walking at similar to 70% of maximal aerobic capacity daily for 7 days. The exercise program resulted in improvements in insulin action in the absence of weight loss. Glucose disposal rates during the euglycemic clamp were significantly increased at both hyperinsulinemic stages after training (40 mU: 1.84 +/- 0.32 to 2.67 +/- 0.37 mg.kg(-1).min(-1), P < 0.0001; 1,000 mU: 7.57 +/- 0.61 to 8.84 +/- 0.56 mg.kg(-1).mi(n-)1, P = 0.008). Hepatic glucose production, both in the basal state (3.17 +/- 0.43 vs. 2.54 +/- 0.26 mg.kg(-1)min(-1), P = 0.05) and during the 40-mU clamp stage (1.15 +/- 0.41 vs. 0.46 +/- 0.20 mg.kg(-1).min(-1), P = 0.03), was significantly reduced after training. One week of vigorous exercise training can induce significant improvements in insulin action in type 2 diabetes. These improvements include increased peripheral insulin sensitivity and responsiveness as well as enhanced suppression of hepatic glucose production.