DHH1/DDX6-like RNA helicases maintain ephemeral half-lives of stress-response mRNAs
DHH1/DDX6-like RNA helicases maintain ephemeral half-lives of stress-response mRNAs
复制标题
DHH1/ ddx6样RNA解旋酶维持应激反应mrna的短暂半衰期
DOI：
10.1038/s41477-020-0681-8
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发表时间：
2020-06-01
期刊：
影响因子：
18
通讯作者：
Bailey-Serres, Julia
中科院分区：
文献类型：
--
作者：
Chantarachot, Thanin;Sorenson, Reed S.;Bailey-Serres, Julia
当病原体压力较弱时，防御基因必须关闭，以有利于生长和发育计划。三种RNA解旋酶通过控制胁迫特异性mRNA的稳定和翻译来参与这种抑制。基因转录通过信使RNA降解过程来平衡，信使RNA降解过程调节转录物的质量和数量。在这里，我们表明，进化上保守的DHH 1/DDX 6样RNA解旋酶的拟南芥控制短暂的一个子集的细胞mRNA。这些RNA解旋酶与加工体和应激颗粒的关键标志物共定位，并有助于其亚细胞动力学。它们的功能是限制在非应激条件下参与自身免疫和生长抑制的应激应答mRNA的早熟积累和核糖体缔合。鉴于这种RNA解旋酶亚家族的保守性，它们可以控制不同真核生物中条件调节mRNA的基础水平，加速反应而不受惩罚。
Defence genes must be switched off when pathogen pressure is weak to favour growth and development programmes. Three RNA helicases participate in this repression by controlling how stress-specific mRNAs are stabilized and translated.Gene transcription is counterbalanced by messenger RNA decay processes that regulate transcript quality and quantity. We show here that the evolutionarily conserved DHH1/DDX6-like RNA hellicases of Arabidopsis thaliana control the ephemerality of a subset of cellular mRNAs. These RNA helicases co-localize with key markers of processing bodies and stress granules and contribute to their subcellular dynamics. They function to limit the precocious accumulation and ribosome association of stress-responsive mRNAs involved in auto-immunity and growth inhibition under non-stress conditions. Given the conservation of this RNA helicase subfamily, they may control basal levels of conditionally regulated mRNAs in diverse eukaryotes, accelerating responses without penalty.