Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats
Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats
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DOI：
10.1152/physiolgenomics.00080.2001
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发表时间：
2002-02-28
影响因子：
4.6
通讯作者：
Rapp, JP
中科院分区：
文献类型：
--
作者：
Garrett, MR;Rapp, JP
在此之前，我们报道了一个跨越大鼠5号染色体大区域的同源品系S.Lew(5)的构建。Lewis(Lew)品系是供体，Dahl盐敏感(S)品系是受体。该同基因株含有一个血压数量性状基因座(QTL)。在目前的工作中，从S.Lew(5)中构建了一系列9个同源亚株，该亚株定义了两个紧密联系的血压QTL，在以前被认为只包含一个的区域。这两个QTL上的低低血压等位基因都是对血压产生重大影响所必需的。两个LOW等位基因单独对血压都没有显著影响。两个QTL定位在6.3和4.6 cM区域，相距1.0 cM。
Previously we reported the construction of a congenic strain, S. LEW( 5), spanning a large region of rat chromosome 5. The Lewis (LEW) strain was the donor, and the Dahl salt-sensitive (S) strain was the recipient. The congenic strain included a blood pressure quantitative trait locus (QTL). In the present work, a series of nine congenic substrains were constructed from S. LEW( 5) which defined two closely linked blood pressure QTL in the region previously thought to contain only one. LEW low-blood-pressure alleles at both QTL were required for a major effect on blood pressure. Neither LEW allele alone had a significant effect on blood pressure. The two QTL were localized to regions 6.3 and 4.6 cM, and these were 1.0 cM apart.