Sympathetic nervous system activity and the heart.
Sympathetic nervous system activity and the heart.
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DOI：
10.1093/ajh/2.12.353s
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发表时间：
1989-12
影响因子：
3.2
通讯作者：
J. Izzo
中科院分区：
文献类型：
--
作者：
J. Izzo
交感神经系统被认为是心血管对急性应激时循环需求增加、心率和收缩力增强以及周围血管张力改变的关键机制。然而，越来越多的人认为这些生理反应会引起长期的不良反应，如心肌功能改变；肾、全身和冠状血管收缩；室性心律失常;还有左心室肥厚——对一些心血管疾病患者来说。尽管评估血浆儿茶酚胺和定量交感神经活动的新技术正在增加我们的知识，但交感神经系统如何影响心血管疾病的病理生理尚不完全清楚。然而，对交感神经系统刺激的生理反应的回顾揭示了它们在心血管疾病过程中的可能作用。
The sympathetic nervous system has been viewed as the critical mechanism for cardiovascular response to increased circulatory needs during acute stress, augmenting cardiac rate and contractility and changing peripheral vascular tone. These physiologic responses, however, are increasingly thought to cause long-term adverse effects--such as altered myocardial function; renal, systemic, and coronary vasoconstriction; ventricular arrhythmias; and left ventricular hypertrophy--for some patients with cardiovascular disease. How the sympathetic nervous system affects the pathophysiology of cardiovascular diseases is not fully understood, although new techniques for assessing plasma catecholamines and for quantitating sympathetic activity are adding to our knowledge. Nevertheless, a review of the physiologic responses to sympathetic nervous system stimulation reveals much about their possible role in the cardiovascular disease process.