Copper‐Catalyzed Cross‐Coupling Reactions of Nucleobases with Arylboronic Acids: An Efficient Access to N‐Arylnucleobases.
Copper‐Catalyzed Cross‐Coupling Reactions of Nucleobases with Arylboronic Acids: An Efficient Access to N‐Arylnucleobases.
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铜催化核碱基与芳基硼酸的交叉偶联反应：有效获取 N-芳基核碱基。
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Xiao‐Qi Yu
中科院分区：
文献类型：
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作者：
Yang Yue;Zhang;Bo Wu;Chuan‐qin Xia;Xiao‐Qi Yu
发现了一种简单铜盐催化的芳基硼酸与碱基直接N-芳基化的有效途径。以甲醇和水为混合溶剂，在室温下45 min内得到了高产率的N-芳基碱基。在这些条件下，偶联反应容许在苯基硼酸的o-、m-或p-位上的供电子和吸电子取代基，并且以中等至优异的产率给出相应的偶联产物。实验结果表明，该路线是合成N-芳基核碱基的最有效、简便、温和的方法。（© Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2005）
An efficient avenue for the direct N-arylation of nucleobases with arylboronic acids that is catalyzed by simple copper salts was discovered. The N-arylnucleobases were obtained in excellent yields at room temperature within 45 min when methanol and water were used as a mixed solvent. Under these conditions, the coupling reaction tolerates both electron-donating and electron-withdrawing substituents at the o-, m-, or p-positions of phenylboronic acid and gives the corresponding coupling products in moderate to excellent yields. Experimental results show that this route is the most efficient, facile, and mild method for the synthesis of N-arylnucleobases. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
9-[(羟甲基)苯基]腺嘌呤：腺苷脱氨酶的新芳基腺嘌呤底物。
影响因子：
2.7
作者：
Brakta,Mohamed;Murthy,Devangachinta;Ellis,L'Ouverture;Phadtare,Shashikant
通讯作者：
Phadtare,Shashikant