Effects of household sharing on high density lipoprotein and its subfractions.
Effects of household sharing on high density lipoprotein and its subfractions.
复制标题
家庭共享对高密度脂蛋白及其亚组分的影响。
DOI：
10.1002/gepi.1370020403
复制
发表时间：
1985
影响因子：
2.1
通讯作者：
Williams,RR
中科院分区：
文献类型：
--
作者：
Hasstedt,SJ;Kuida,H;Ash,KO;Williams,RR
在观察到的高密度脂蛋白胆固醇（HDL‐C）和亚组分hdl2和HDL3的方差中，家庭效应占显著比例。研究发现，19.3%的HDL - C变异可归因于少年同胞效应（18岁以下）；17.4%的hd2变异可归因于兄弟姐妹效应（任何年龄）；22.1%和32.6%的hdl3变异可分别归因于亲代效应和兄弟姐妹效应（任何年龄）。此外，可加性遗传效应分别占HDL‐C、HDL2和HDL3变异的56.5%、37.3%和28.3%。这些是使用方差成分模型对54个犹他家系成员的2149个HDL - C水平和14个家系子集的337个hdl2和hdl3水平进行的最大似然估计。
Household effects accounted for significant proportions of the observed variance of high density lipoprotein cholesterol (HDL‐C) and subfractions HDL2and HDL3. It was found that 19.3% of HDL‐C variance could be attributed to a juvenile sib effect (under age 18); 17.4% of HDL2variance could be attributed to a sib effect (of any age); and 22.1% and 32.6% of the HDL3variance could be attributed to a parent‐offspring effect and a sib effect (of any age), respectively. In addition, additive genetic effects accounted for 56.5%, 37.3%, and 28.3% of the variances of HDL‐C, HDL2, and HDL3, respectively. These are maximum likelihood estimates obtained using a variance components model on 2,149 HDL‐C levels measured on members of 54 Utah pedigrees, and 337 HDL2and HDL3levels measured on a subset of 14 pedigrees.