Association of shorter telomeres with coronary artery disease in Indian subjects
Association of shorter telomeres with coronary artery disease in Indian subjects
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DOI：
10.1136/hrt.2008.150250
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发表时间：
2009-04-01
期刊：
影响因子：
5.7
通讯作者：
Samani, N. J.
中科院分区：
文献类型：
--
作者：
Mukherjee, M.;Brouilette, S.;Samani, N. J.
目的：针对白人的研究表明，作为生物衰老标志的端粒长度在患有冠状动脉疾病 (CAD) 的个体中较短。南亚印度人的 CAD 患病率很高，尤其是早发性 CAD。我们检查了印度受试者中端粒长度与 CAD 的关联。设计：病例对照研究。地点：印度孟买。受试者：238 名连续患者（年龄 29-82 岁），入住 Cumballa Hill 医院进行冠状动脉检查或治疗，以及来自同一地区的 238 名对照受试者（年龄 30-87 岁），没有任何 CAD 的临床证据。方法：使用聚合酶链测量平均白细胞端粒长度结果：与对照相比，CAD 病例中的 T/S 比显着较低（病例 1.21（95% CI 1.16 至 1.26）；对照 1.33（1.28 至 1.38）；p = 0.0003），相当于大约 166 个碱基对。调整其他临床特征后，差异仍然显着（p = 0.002）。与混合饮食受试者相比，素食受试者的端粒有更长的趋势（素食者 1.31（1.25 至 1.38）；混合 1.25（1.18 至 1.33）；p = 0.088），而有 CAD 阳性家族史 (FH) 的受试者则有更短的端粒趋势（+ve FH 1.25（1.18 至 1.32）；-ve FH 1.31（1.24 至 1.38）；p = 0.094）。结论：患有 CAD 的印度裔受试者的端粒比没有此类病史的受试者短。这一发现提供了进一步的证据，表明 CAD 受试者的端粒生物学发生了改变。
Objective: Studies in white people have shown that telomere length, a marker of biological ageing, is shorter in individuals with coronary artery disease (CAD). South Asian Indians have a high prevalence of CAD, especially premature CAD. We examined the association of telomere length with CAD in Indian subjects.Design: Case-control study.Setting: Mumbai, India.Subjects: 238 consecutive patients (aged 29-82 years), admitted to Cumballa Hill Hospital for coronary investigations or treatment and 238 control subjects (aged 30 87 years) from the same area without any clinical evidence of CAD.Methods: Mean leucocyte telomere length was measured using a polymerase chain reaction (PCR)-based assay and expressed as a ratio (T/S ratio) of the telomere signal to that of a control single copy gene.Results: T/S ratio was significantly lower in CAD cases compared with controls (cases 1.21 (95% CI 1.16 to 1.26); controls 1.33 (1.28 to 1.38); p = 0.0003), equivalent to approximately 166 base pairs. The difference remained significant after adjustment for other clinical characteristics (p = 0.002). There were trends towards longer telomeres in vegetarian subjects compared with subjects on a mixed diet (vegetarians 1.31 (1.25 to 1.38); mixed 1.25 (1.18 to 1.33); p = 0.088) and shorter telomeres in subjects with a positive family history (FH) for CAD (+ve FH 1.25 (1.18 to 1.32); -ve FH 1.31 (1.24 to 1.38); p = 0.094).Conclusion: Subjects of Indian ethnicity with CAD have shorter telomeres than subjects without such a history. The finding provides further evidence that telomere biology is altered in subjects with CAD.