Protective effects of dietary arginine supplementation against oxidative stress in weaned piglets
Protective effects of dietary arginine supplementation against oxidative stress in weaned piglets
复制标题
日粮中添加精氨酸对断奶仔猪氧化应激的保护作用
DOI：
10.1017/s0007114512004321
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发表时间：
2012-11
影响因子：
3.6
通讯作者：
Chen, Daiwen
中科院分区：
文献类型：
--
作者：
Zheng, Ping;Yu, Bing;He, Jun;Tian, Gang;Luo, Yuheng;Mao, Xiangbing;Zhang, Keying;Che, Lianqiang;Chen, Daiwen
氧化应激对动物有害。以往的研究表明，精氨酸(Arg)可能是一种潜在的抗氧化应激物质。本研究旨在探讨精氨酸对仔猪氧化应激保护作用的可能机制。将36头仔猪随机分为6组，每组6个重复。在试验第1周，分别饲喂基础日粮、基础日粮中添加0.8%(ArgM)和1.6%(Argh)的L精氨酸，每组2个处理。在第8天，给仔猪腹腔注射敌草净(10 mg/kg体重)或无菌生理盐水。结果表明，日粮中添加精氨酸对仔猪的生长性能无显著影响，氧化应激显著降低仔猪的生长性能(P<；0.05)。然而，Argh可减轻氧化应激对采食量的负面影响，并显著提高氧化应激下肝脏的总抗氧化能力(P<；0.05)。ArgM和Argh均能提高氧化应激小鼠血浆谷胱甘肽过氧化物酶和超氧化物歧化酶活性，降低肝脏IL-6和肿瘤坏死因子-α基因水平(P<；0.05)。本研究不仅表明精氨酸可以作为一种潜在的营养物质，通过增强抗氧化能力和抑制炎性细胞因子的表达来缓解氧化应激反应，而且该结果还表明，使用膳食营养成分来缓解氧化应激反应值得进一步关注。
Oxidative stress is detrimental to animals. Previous studies have indicated that arginine (Arg) may function as a potential substance against oxidative stress. The present study was conducted to explore the potential mechanisms behind the Arg-induced protective effects against oxidative stress in piglets. A total of thirty-six piglets were randomly allocated to six groups with six replicates per group. Piglets were subjected to three dietary treatments (namely two groups per treatment) in week 1 and fed with a basal diet (ArgL) or the basal diet supplemented with 0·8 % (ArgM) or 1·6 % (ArgH) l-Arg, respectively. On day 8, piglets were injected intraperitoneally either with diquat (10 mg/kg body weight) or sterile saline. The whole trial lasted 11 d. Results showed that dietary Arg supplementation did not affect growth performance in week 1. Oxidative stress significantly decreased the growth performance of piglets (P< 0·05). However, ArgH attenuated the negative effects of oxidative stress on feed intake and significantly increased the total antioxidant capacity in the liver under oxidative stress (P< 0·05). Both ArgM and ArgH enhanced the activities of plasma glutathione peroxidases and superoxide dismutases and decreased the IL-6 and TNF-α mRNA level in the liver under oxidative stress (P< 0·05). The present study not only shows that Arg can function as a potential nutrient to alleviate oxidative stress responses through the enhancement of antioxidant capacity, and inhibition of the expression of inflammatory cytokines, but the results also suggest that alleviation of oxidative stress responses using dietary nutrient components deserves further attention in the future.
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影响因子：
6.4
作者：
B. Kusters;M. Peppelman;H. Timmers;J. Lenders;A. Hermus
通讯作者：
B. Kusters;M. Peppelman;H. Timmers;J. Lenders;A. Hermus
影响因子：
4.2
作者：
Wu, GY;Fang, YZ;Turner, ND
通讯作者：
Turner, ND
影响因子：
15.9
作者：
Xing, Z;Gauldie, J;Achong, MK
通讯作者：
Achong, MK
影响因子：
15.9
作者：
Furukawa, S.;Fujita, T.;Shimomura, I.
通讯作者：
Shimomura, I.
影响因子：
2.7
作者：
K. Yumino;I. Kawakami;M. Tamura;Takaaki Hayashi;Masao Nakamura
通讯作者：
K. Yumino;I. Kawakami;M. Tamura;Takaaki Hayashi;Masao Nakamura