The different effects of three Drosophila melanogaster dFMRFamide-containing peptides on crop contractions suggest these structurally related peptides do not play redundant functions in gut
The different effects of three Drosophila melanogaster dFMRFamide-containing peptides on crop contractions suggest these structurally related peptides do not play redundant functions in gut
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DOI：
10.1016/s0196-9781(02)00179-1
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发表时间：
2002-11-01
期刊：
影响因子：
3
通讯作者：
Nichols, R
中科院分区：
文献类型：
--
作者：
Duttlinger, A;Berry, K;Nichols, R
果蝇dFMRFamide基因产物TPAEDFMRFamide减少了作物的收缩。然而，同样编码在dFMRFamide中的DPKQDFMRFamide和SDNFMRFamide并不影响作物的运动性，这表明这些多肽在作物中不是功能冗余的，它们独特的N-端结构对活性是重要的。TPAEDFMRFamide特异性抗血清没有对作物染色，这表明它是一种激素。TDVDHVFLRFamide(DMS)，编码在黑腹果蝇肌肉抑制素中，可以阻止作物收缩。TPAEDFMRFamide和DMS都含有一个RFamide C-末端；然而，它们对作物收缩的影响不同，这表明有独特的受体或不同的配体：这些结构相关的多肽存在受体结合要求。(C)2002 Elsevier Science Inc.保留所有权利。
A Drosophila melanogaster dFMRFamide gene product, TPAEDFMRFamide, decreased crop contractions. However, DPKQDFMRFamide and SDNFMRFamide, also encoded in dFMRFamide, did not affect crop motility, which suggests these peptides are not functionally redundant in the crop and their unique N-terminal structures are important for activity. TPAEDFMRFamide- specific antisera did not stain the crop, which suggests it acts as a hormone. TDVDHVFLRFamide (DMS), encoded in D. melanogaster myosuppressin, stops crop contractions. TPAEDFMRFamide and DMS each contains a RFamide C-terminus; however, their effects on crop contractions differ, which suggests that unique receptors or different ligand:receptor binding requirements exist for these structurally related peptides. (C) 2002 Elsevier Science Inc. All rights reserved.