Biologically active polymeric sequestrants: Design, synthesis, and therapeutic applications
Biologically active polymeric sequestrants: Design, synthesis, and therapeutic applications
复制标题
DOI：
10.1351/pac200779091521
复制
发表时间：
2007-09-01
影响因子：
1.8
通讯作者：
Holmes-Farley, S. Randall
中科院分区：
文献类型：
--
作者：
Dhal, Pradeep K.;Huval, Chad C.;Holmes-Farley, S. Randall
近年来，表现出固有生物活性的功能聚合物作为基于聚合物的人类治疗剂受到越来越多的关注。这些聚合物药物表现出独特的药物特性，与传统的小分子药物根本不同。然而，与聚合物药物递送系统不同，具有内在治疗特性的聚合物的例子相对较少。凭借其高分子量的特性，这些聚合物药物可以被限制在胃肠道（GI）内，在那里它们可以选择性地识别、结合和清除体内的目标致病物质。这些聚合物药物仅限于胃肠道且不可生物降解，因此不存在与传统全身药物相关的毒性作用。本报告重点介绍了合理设计和合成适当功能聚合物的最新进展，这些进展产生了许多有前途的基于聚合物的治疗剂，包括一些市售产品。
In recent years, functional polymers exhibiting inherently biological activities have been receiving increasing attention as polymer-based human therapeutic agents. These polymeric drugs exhibit unique pharmaceutical properties that are fundamentally different from their traditional small-molecule counterparts. However, unlike polymeric drug delivery systems, examples of polymers possessing intrinsically therapeutic properties are relatively scarce. By virtue of their high-molecular-weight characteristics, these polymeric drugs can be confined to the gastrointestinal (GI) tract, where they can selectively recognize, bind, and remove target disease-causing substances from the body. Being confined to the GI tract and non-biodegradable, these polymeric drugs are free from toxic effects that are associated with traditional systemic drugs. This report highlights recent developments in the rational design and synthesis of appropriate functional polymers that have resulted in a number of promising polymer-based therapeutic agents, including some marketed products.