Trait impulsivity is related to ventral ACC and amygdala activity during primary reward anticipation
Trait impulsivity is related to ventral ACC and amygdala activity during primary reward anticipation
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DOI：
10.1093/scan/nsu023
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发表时间：
2015-01-01
影响因子：
4.2
通讯作者：
Simmons, W. Kyle
中科院分区：
文献类型：
--
作者：
Kerr, Kara L.;Avery, Jason A.;Simmons, W. Kyle
特质冲动的特征是行为去抑制和轻率的决策，导致许多适应不良的行为。以往的研究表明，特质冲动性与奖赏敏感性和情绪调节相关的脑区活动有关，但很少有人知道这种关系的背景下立即可用的主要奖励。这是不幸的，因为在这些情况下的冲动可能导致不健康的行为，包括不良的食物选择，危险的药物使用和危险的性行为。此外，很少有人知道奖励和情感神经回路的整合之间的关系，作为衡量休息状态功能连接，并在日常生活中的特质冲动，作为衡量常用的人格问卷。因此，我们要求健康的成年人接受功能性磁共振成像任务，在这项任务中，他们看到了暗示即将口服奖励味道的线索，以及静息状态扫描。特质冲动与前扣带皮层（ACC）和杏仁核在预期初级奖励时的激活增加有关。此外，静息状态下前扣带回和右侧杏仁核之间的功能连接与特质冲动性呈负相关。这些发现表明，特质冲动性不仅与ACC-杏仁核的激活有关，而且与这些区域彼此之间的紧密耦合程度有关。
Trait impulsivity is characterized by behavioral disinhibition and rash decision-making that contribute to many maladaptive behaviors. Previous research demonstrates that trait impulsivity is related to the activity of brain regions underlying reward sensitivity and emotion regulation, but little is known about this relationship in the context of immediately available primary reward. This is unfortunate, as impulsivity in these contexts can lead to unhealthy behaviors, including poor food choices, dangerous drug use and risky sexual practices. In addition, little is known about the relationship between integration of reward and affective neurocircuitry, as measured by resting-state functional connectivity, and trait impulsivity in everyday life, as measured with a commonly used personality inventory. We therefore asked healthy adults to undergo a functional magnetic resonance imaging task in which they saw cues indicating the imminent oral administration of rewarding taste, as well as a resting-state scan. Trait impulsivity was associated with increased activation during anticipation of primary reward in the anterior cingulate cortex (ACC) and amygdala. Additionally, resting-state functional connectivity between the ACC and the right amygdala was negatively correlated with trait impulsivity. These findings demonstrate that trait impulsivity is related not only to ACC-amygdala activation but also to how tightly coupled these regions are to one another.