Consumption of a Legume-Enriched, Low-Glycemic Index Diet Is Associated with Biomarkers of Insulin Resistance and Inflammation among Men at Risk for Colorectal Cancer
Consumption of a Legume-Enriched, Low-Glycemic Index Diet Is Associated with Biomarkers of Insulin Resistance and Inflammation among Men at Risk for Colorectal Cancer
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DOI：
10.3945/jn.109.114249
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发表时间：
2010-01-01
影响因子：
4.2
通讯作者：
Lanza, Elaine
中科院分区：
文献类型：
--
作者：
Hartman, Terryl J.;Albert, Paul S.;Lanza, Elaine
据我们所知，豆类炎症喂养实验是第一个随机交叉喂养试验，测试富含豆类的低血糖指数（GI）饮食对结直肠腺瘤和胰岛素抵抗（IR）状态的男性的影响。这项研究旨在测试在体重稳定的条件下，富含豆类的饮食与健康的美国（HA）饮食相比的效果。主要目的是评估对C反应蛋白（CRP）和C肽水平的影响。次要目的是评估IR状态或腺瘤病史的变化。共有64名男性在前2年内完成结肠镜检查，他们以随机顺序食用2种饮食，每种饮食持续4周，间隔一个洗脱期。饮食为富含豆类（250 g/d）、低GI（GI 38）饮食和高GI（GI 69）HA饮食。我们在饮食期开始和结束时测量空腹血糖、胰岛素、C肽、CRP和可溶性肿瘤坏死因子-α受体I和II（sTNFRI/II）。食用豆类和HA饮食的参与者分别有利地改善了CRP（-20.2和-18.3%）和sTNFRI（-3.7和-4.4%）浓度。sTNFRII浓度在豆类饮食期间略微下降（-3.8%; P = 0.060），在HA饮食期间显著下降（-5.1%; P < 0.001）。在豆类（+1.8%）和HA（-2.2%）饮食期间，空腹葡萄糖均显著增加。只有葡萄糖的变化在饮食期间不同。血清C-肽和血浆胰岛素水平没有改变的参与者消费的饮食。健康的饮食变化可以改善IR和炎症的生物标志物。J.营养140：60-67，2010.
The Legume Inflammation Feeding Experiment is, to our knowledge, the first randomized crossover feeding trial testing the effects of a legume-enriched, low-glycemic index (GI) diet among men characterized for colorectal adenomas and insulin resistance (IR) status. This study was designed to test the effects of a legume-enriched diet compared with a healthy American (HA) diet under weight-stable conditions. The primary objective was to assess effects on C-reactive protein (CRP) and C-peptide levels. The secondary objective was to assess changes by IR status or history of adenomas. A total of 64 men who completed a colonoscopy within the previous 2 y consumed 2 diets in random order each for 4 wk separated by a washout period. The diets were a legume-enriched (250 g/d), low-GI (GI 38) diet and a high-GI (GI 69) HA diet. We measured fasting glucose, insulin, C-peptide, CRP, and soluble tumor necrosis factor-alpha receptors I and II (sTNFRI/II) at the beginning and end of the diet periods. Participants who consumed both the legume and HA diets had favorably improved CRP (-20.2 and -18.3%) and sTNFRI (-3.7 and -4.4%) concentrations, respectively. The sTNFRII concentrations declined marginally during the legume diet period (-3.8%; P = 0.060) and significantly during the HA diet period (-5.1%; P < 0.001). Fasting glucose increased significantly during both the legume (+1.8%) and HA (-2.2%) diet periods. Only the changes in glucose differed between the diet periods. Serum C-peptide and plasma insulin levels did not change in participants consuming either diet. Healthful dietary changes can improve biomarkers of IR and inflammation. J. Nutr. 140: 60-67, 2010.