Allograft inflammatory factor-1 is an independent prognostic indicator that regulates β-catenin in gastric cancer.
Allograft inflammatory factor-1 is an independent prognostic indicator that regulates β-catenin in gastric cancer.
复制标题
DOI：
10.3892/or.2013.2915
复制
发表时间：
2014-02
期刊：
影响因子：
4.2
通讯作者：
Yang Ye;Shuhan Miao;Rongzhu Lu;Xiaowei Xia;Yansu Chen;Jianbing Zhang;Xuming Wu;Song He;Fulin Qiang;Jianwei Zhou
中科院分区：
文献类型：
--
作者：
Yang Ye;Shuhan Miao;Rongzhu Lu;Xiaowei Xia;Yansu Chen;Jianbing Zhang;Xuming Wu;Song He;Fulin Qiang;Jianwei Zhou
以往的研究表明，同种异体移植炎性因子-1（AIF-1）蛋白的表达似乎在恶性肿瘤中增加，并与宫颈癌的预后较差相关，而其在胃癌中的作用尚未报道。我们通过免疫组化分析了78例癌组织和相应的非癌组织中AIF-1的表达。与其他癌症相比，我们发现AIF-1蛋白水平在78例胃癌组织中的53例（67.9%）中与匹配的正常组织相比显著降低。用7对新鲜胃癌组织和匹配的邻近正常组织进一步证实了这一点。AIF-1低表达与胃癌患者较差的临床病理特征以及总生存率降低显著相关（P<0.001）。此外，AIF-1基因敲低可明显促进BGC-823和SGC-7901胃癌细胞的增殖、迁移和β-catenin的表达。综上所述，我们首次提供证据表明AIF-1表达水平可作为胃癌的保护性预后指标。
Previous studies have revealed that expression of allograft inflammatory factor-1 (AIF-1) protein appears to be increased in malignancies and is correlated with a poorer prognosis in cervical cancer, while its role in gastric cancer has not been reported. We analyzed the expression of AIF-1 in 78 cancer lesions and the corresponding non-cancerous tissues by immunohistochemistry. In contrast with other cancers, we found that AIF-1 protein levels were significantly decreased in 53 of the 78 (67.9%) gastric cancer tissues when compared with the matched normal tissues. This was further confirmed using 7 pairs of fresh gastric cancer tissues and matched adjacent normal tissues. Low tumoral AIF-1 expression was significantly correlated with less favorable clinicopathological characteristics, as well as with reduced overall survival (P<0.001) in the gastric cancer patients. Furthermore, knockdown of AIF-1 obviously increased proliferation, migration and β-catenin expression in BGC-823 and SGC-7901 gastric cancer cells. Taken together, for the first time, we provide evidence that the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer.