FAMILIAL AGGREGATION OF LEISHMANIA-CHAGASI INFECTION IN NORTHEASTERN BRAZIL
FAMILIAL AGGREGATION OF LEISHMANIA-CHAGASI INFECTION IN NORTHEASTERN BRAZIL
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DOI：
10.4269/ajtmh.1995.52.364
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发表时间：
1995-04-01
影响因子：
3.3
通讯作者：
KRIEGER, H
中科院分区：
文献类型：
--
作者：
CABELLO, PH;LIMA, AMVMD;KRIEGER, H
对来自内脏利什曼病流行区(巴西巴伊亚州雅各比纳)243个核心家庭的1,604人样本进行了研究，以揭示家庭内感染模式。显著的父亲对子女、母亲对子女和兄弟姐妹对兄弟姐妹的关联，与不显著的父亲对母亲的关联相比，清楚地表明感染的家族聚集性，强烈表明至少有部分基因参与。
A sample of 1,604 individuals belonging to 243 nuclear families from an endemic area of visceral leishmaniasis (Jacobina, Bahia State, Brazil) was studied to disclose the intrafamilial pattern of infection. Significant father to offspring, mother to offspring, and sibling to sibling associations, in contrast a with nonsignificant father to mother association, clearly indicate a familial aggregation of the infection, with a strong suggestion of at least partial genetic involvement.