Proton Pump Inhibitors What the Internist Needs to Know
Proton Pump Inhibitors What the Internist Needs to Know
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DOI：
10.1016/j.mcna.2018.08.001
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发表时间：
2019-01-01
影响因子：
5.9
通讯作者：
Spechler, Stuart Jon
中科院分区：
文献类型：
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作者：
Spechler, Stuart Jon
本报告回顾了质子泵抑制剂 (PPI) 抑制胃酸的生理学以及 PPI 与其抑酸作用无关的抗炎作用。讨论了 PPI 使用的有效适应症，以及通过无法建立因果关系的观察性研究中的弱关联确定的 PPI 的假定不良反应。尽管支持这些不利影响有效性的证据很弱，但也没有足够的证据来消除这些风险。该报告强调了质子泵抑制剂 (PPI) 处方的频繁使用不当，并鼓励医生仔细考虑患者的质子泵抑制剂 (PPI) 治疗适应症。
This report reviews the physiology of gastric acid suppression by proton pump inhibitors (PPIs) and anti-inflammatory effects of PPIs that are independent of their acid-suppressive effects. Valid indications for PPI use are discussed, as are putative adverse effects of PPIs that have been identified through weak associations in observational studies that cannot establish cause-and-effect relationships. Although evidence supporting the validity of these adverse effects is weak, there is also insufficient evidence to dismiss the risks. The report emphasizes how PPIs frequently are prescribed inappropriately and encourages physicians to carefully consider the indication for PPI therapy in their patients.