Preeclampsia: linking placental ischemia with cardiovascular-renal dysfunction.

Preeclampsia: linking placental ischemia with cardiovascular-renal dysfunction.
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DOI：
10.1152/physiologyonline.2001.16.6.282
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发表时间：
2001-12
期刊：
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
影响因子：
--
通讯作者：
B. Alexander;W. Bennett;R. Khalil;J. Granger
B. Alexander;W. Bennett;R. Khalil;J. Granger
中科院分区：
其他
文献类型：
--
作者：
B. Alexander;W. Bennett;R. Khalil;J. Granger

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先兆子痫期间的胎盘缺血被认为导致母体血管内皮的广泛激活/功能障碍。这导致内皮素和血栓素的形成增加，一氧化氮和前列环素的形成减少。这些内皮异常反过来又通过损害肾压尿钠排泄和增加总外周阻力而引起高血压。
Placental ischemia during preeclampsia is thought to lead to widespread activation/dysfunction of the maternal vascular endothelium. This results in enhanced formation of endothelin and thromboxane and decreased formation of nitric oxide and prostacyclin. These endothelial abnormalities, in turn, cause hypertension by impairing renal pressure natriuresis and increasing total peripheral resistance.