Influence of dietary calcium on chlordecone-induced biochemical changes in serum of rat.
Influence of dietary calcium on chlordecone-induced biochemical changes in serum of rat.
复制标题
膳食钙对十氯酮引起的大鼠血清生化变化的影响。
DOI：
10.1006/eesa.1993.1053
复制
发表时间：
1993
影响因子：
6.8
通讯作者：
Ivie,GW
中科院分区：
文献类型：
--
作者：
Chetty,KN;Walker,J;Brown,K;Ivie,GW
雄性Sprague-Dawley大鼠连续15天在钙充足（Ca-S）或钙缺乏（Ca-D）的饮食中摄入不同浓度（百万分之1、10、50和100）的十氯酮。未观察到血清总蛋白的显著变化。然而，血清非蛋白氮化合物（尿素，尿酸，肌酐）和谷草转氨酶，谷草转氨酶，肌酸激酶，碱性磷酸酶显着增加，在50和100 ppm的镉。与喂食钙硫饲料相比，喂食钙硫饲料的大鼠血清中这些成分的含量增加幅度更大。增加血清非蛋白氮化合物和酶表明镉改变肾小球和肝功能。
Male, Sprague-Dawley rats were treated with different (1, 10, 50, and 100 ppm) concentrations of chlordecone (Cd) in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. No significant changes in serum total proteins were observed. However, serum nonprotein nitrogen compounds (urea, uric acid, and creatinine) and glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, creatine kinase, and alkaline phosphatase were significantly increased at 50 and 100 ppm of Cd. Chlordecone induced more increase in these serum components of rats fed with Ca-D as compared to Ca-S diet. Increased serum nonprotein nitrogen compounds and enzymes indicate Cd-altered glomerular and hepatic functions.