Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct γ-Oh-1,N2-propano-2′-deoxyguanosine
Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct γ-Oh-1,N2-propano-2′-deoxyguanosine
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DOI：
10.1021/ja020333r
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发表时间：
2002-08-14
影响因子：
15
通讯作者：
Stone, MP
中科院分区：
文献类型：
--
作者：
Kim, HYH;Voehler, M;Stone, MP
光谱证据表明，在5‘-CPG-3’序列中，由丙烯醛加合物γ-OH-PDG形成了甲醇胺链间交联物。这对于理解丙烯醛引起的CpG序列中DNA损伤的生物过程可能是重要的。
Spectroscopic evidence is presented for the formation of a carbinolamine interchain cross-link in 5‘-CpG-3‘ sequences, arising from the acrolein adduct γ-OH-PdG. This may be important in understanding biological processing of acrolein-induced DNA damage in CpG sequences.