Correlation between cerebral blood flow and items of the Hamilton Rating Scale for Depression in antidepressant-naive patients
Correlation between cerebral blood flow and items of the Hamilton Rating Scale for Depression in antidepressant-naive patients
复制标题
DOI：
10.1016/s0165-0327(03)00049-1
复制
发表时间：
2004-05-01
影响因子：
6.6
通讯作者：
García-Reyna, JC
中科院分区：
文献类型：
--
作者：
Graff-Guerrero, A;González-Olvera, J;García-Reyna, JC
背景：本研究的目的是将重度抑郁症（MDD）患者的基础脑血流量（CBF）与汉密尔顿抑郁量表（HRSD）中21个问题的得分相关联，以确定与每个项目相关的大脑区域。方法：14 名未接受过抗抑郁治疗的单相抑郁症患者（DSM-IV MDD 标准）参与了本研究，HRSD 评分为 2±20 分。 SPECT获得的CBF图像通过SPM99软件进行分析。先验区域（额皮质和边缘区域）的显着相关阈值是 Z 值至少为 2.25 并且由超过 10 个体素形成的簇。结果：1、6、11、20项与右侧额内侧回呈正相关；第7项与双侧额内侧回呈负相关。第 2 项和第 10 项分别与右前扣带回和内侧扣带回呈正相关。第 5 项与左侧杏仁核呈负相关。第 9 项与双侧岛叶呈负相关，第 16 项与右侧岛叶呈负相关。第 12 项和第 14 项分别与右侧和左侧中央前额回呈正相关。局限性：该研究样本量小且仅包括门诊患者。结论：额叶皮层在 MDD 症状的表达中发挥着重要作用。并非所有评估的症状都与一种单一结构相关，这可以解释文献中报道的不同结果。这些初步结果支持了根据症状进行进一步分析的必要性，这些分析可以提供有关 MDD 病理生理学的更具体信息。 (C) 2003 Elsevier B.V. 保留所有权利。
Background: The purpose of this study was to correlate the basal cerebral blood flow (CBF) in patients with major depressive disorder (MDD) with the score for each of the 21 questions in the Hamilton Rating Scale for Depression (HRSD), in order to determine the cerebral regions associated with each item. Methods: Fourteen antidepressant-naive patients with unipolar depression (DSM-IV criteria for MDD) participated in this Study with a HRSD score of 2 20 points. CBF images obtained by SPECT were analyzed by SPM99 software. The significant correlation threshold for a priori regions (frontocortical and limbic regions) was a Z value of at least 2.25 and clusters formed by more than 10 voxels. Results: Items 1, 6, 11 and 20 were positively correlated with right medial frontal gyrus; item 7 was negatively correlated with bilateral medial frontal gyrus. Items 2 and 10 were positively correlated with right anterior and medial cingulate, respectively. Item 5 was negatively correlated with the left amygdala. Item 9 was negatively correlated with bilateral insula, and item 16 with right insula. Items 12 and 14 were positively correlated with right and left precentral frontal gyrus, respectively. Limitations: The small sample size and only out-patients included in the study. Conclusions: The frontal cortex plays an important role in the expression of MDD symptoms. Not all the symptoms evaluated correlated with one single structure, which may explain the diverse results reported in the literature. These preliminary results support the necessity of further analyses by symptoms that could provide more specific information on the pathophysiology of MDD. (C) 2003 Elsevier B.V. All rights reserved.