Effect of suckling isotonic or hypertonic solutions of sodium bicarbonate or glucose on abomasal emptying rate in calves
Effect of suckling isotonic or hypertonic solutions of sodium bicarbonate or glucose on abomasal emptying rate in calves
复制标题
DOI：
10.2460/ajvr.67.8.1377
复制
发表时间：
2006-08-01
影响因子：
1
通讯作者：
Marshall, Tessa S.
中科院分区：
文献类型：
--
作者：
Sen, Ismail;Constable, Peter D.;Marshall, Tessa S.
试验-测定和比较犊牛在吮吸牛奶添加剂或NaHCO 3或葡萄糖的等渗或高渗溶液时的真胃排空率。动物-5头小于30日龄的雄性Holstein-Friesian犊牛。程序-犊牛喂食2 L牛奶添加剂或含对乙酰氨基酚（50 mg/kg）的NaHCO 3或葡萄糖的等渗（300 mOsm/L）或高渗（600 mOsm/L）溶液。静脉血样本和经腹超声皱胃尺寸定期获得喂养后，皱胃腔pH值连续监测放置一个管腔pH电极通过皱胃套管。通过达到最大血浆对乙酰氨基酚浓度的时间、皱胃排空的半衰期的超声测定和管腔pH恢复到餐前值的1个pH单位内的时间来评估皱胃排空速率。结果-高渗NaHCO 3溶液排空慢于等渗NaHCO 3溶液，等渗葡萄糖溶液排空慢于等渗NaHCO 3溶液，高渗葡萄糖溶液的排空比等渗葡萄糖溶液慢。结论和临床相关性-具有高渗透压和葡萄糖浓度的用于口服给药的电解质溶液可能导致脱水腹泻小牛的复苏较慢，因为这种溶液降低了皱胃排空速率，因此降低了溶液递送至胃肠道的速率。小肠在脱水的哺乳期犊牛中，口服电解质溶液是否减慢真胃排空率具有临床重要性仍有待确定。
Objective-To determine and compare the abomasal emptying rates in calves suckling milk replacer or an isotonic or hypertonic solution of NaHCO3 or glucose.Animals-5 male Holstein-Friesian calves that were < 30 days of age.Procedures-Calves were fed 2 L of milk replacer or isotonic (300 mOsm/L) or hypertonic (600 mOsm/L) solutions of NaHCO3 or glucose containing acetaminophen (50 mg/kg). Venous blood samples and transabdominal ultrasonographic abomasal dimensions were obtained periodically after feeding, and abomasal luminal pH was continuously monitored by placement of a luminal pH electrode through an abomasal cannula. Abomasal emptying rate was assessed by the time to maximal plasma acetaminophen concentration, ultrasonographic determination of the half-time of abomasal emptying, and the time for luminal pH to return to within 1 pH unit of the preprandial value.Results-Hypertonic NaHCO3 solution was emptied slower than an isotonic NaHCO3 solution, isotonic glucose solution was emptied slower than an isotonic NaHCO3 solution, and hypertonic glucose solution emptied slower than an isotonic glucose solution.Conclusions and Clinical Relevance-An electrolyte solution for oral administration with a high osmolarity and glucose concentration may lead to a slower resuscitation of dehydrated diarrheic calves because such solutions decrease the abomasal emptying rate and therefore the rate of solution delivery to the small intestine. Whether slowing of the abomasal emptying rate in dehydrated diarrheic calves suckling an oral electrolyte solution is clinically important remains to be determined.