Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution in vivo
Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution in vivo
复制标题
富含血小板血浆对体内毛囊重建的促进作用
DOI：
10.1111/dsu.12292
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发表时间：
2013-12-01
影响因子：
2.4
通讯作者：
Hu, Zhi-Qi
中科院分区：
文献类型：
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作者：
Miao, Yong;Sun, Ya-Bin;Hu, Zhi-Qi
背景富含血小板血浆（Platelet-rich plasma，PRP）含有多种生长因子，已引起医学界的广泛关注。目的探讨PRP对毛囊（hair follicle，HF）重建的影响。方法将新鲜分离的表皮细胞和培养的毛乳头细胞（dermal papilla cells，DPC）与不同浓度的活化PRP混合，转移到移植室中，植入裸鼠背部皮肤。移植后1周取出小室，连续4周监测HF形成情况。
BackgroundPlatelet-rich plasma (PRP) containing various growth factors has attracted attention in various medical fields. PRP has recently been used during hair transplantation to increase hair density.ObjectiveTo investigate the effects of PRP on hair follicle (HF) reconstitution.Methods and MaterialsFreshly isolated epidermal cells and cultured dermal papilla cells (DPCs) were mixed with various concentrations of activated PRP and transferred to a grafting chamber that was implanted onto the dorsal skin of nude mice. The chambers were removed 1week after grafting, and HF formation was monitored for 4weeks.ResultsWe observed a significant difference (p