Comparing the Human and Fish Genomes
Comparing the Human and Fish Genomes
复制标题
比较人类和鱼类基因组
DOI：
10.1002/9780470015902.a0021004.pub2
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Morishita S
中科院分区：
文献类型：
--
作者：
Nakatani Y;Qu W;Morishita S
在过去的6亿年里，脊椎动物的基因组是如何进化的？1970年，基于有限的观察，Ohno假设全基因组复制事件发生在早期脊椎动物中，并且对增加脊椎动物的复杂性至关重要。然而，这个问题仍然是一个生物学上的难题。近年来，许多脊椎动物基因组测序的快速进展揭示了对进化过程的基本见解，鱼类和人类基因组的比较基因组学对于为大野耐一的假设提供结论性支持是必不可少的。
How have the genomes of vertebrates evolved over the last 600 million years? In 1970, based on limited observations, Ohno postulated that whole genome duplication events took place in early vertebrates and were essential to increasing complexity of vertebrates. This issue, however, remains a biological quandary. Recent rapid progress in sequencing the genomes of many vertebrates has revealed fundamental insights into the evolutionary process, and the comparative genomics of the fish and human genomes is indispensable for providing conclusive support to Ohno's hypothesis.