Monocytes as a diagnostic marker of cardiovascular diseases
Monocytes as a diagnostic marker of cardiovascular diseases
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DOI：
10.1016/j.imbio.2012.01.008
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发表时间：
2012-05-01
期刊：
影响因子：
2.8
通讯作者：
Kzhyshkowska, Julia
中科院分区：
文献类型：
--
作者：
Gratchev, Alexei;Sobenin, Igor;Kzhyshkowska, Julia
炎症是心血管疾病的重要致病因素。炎症过程诱导生物体系统性变化，这些变化被先天免疫系统的细胞所感知。这些系统性变化包括能够激活血液循环中单核细胞的可溶性因子浓度增加，因此单核细胞代表了用于诊断用途的高度有吸引力的细胞群体。迄今为止，循环单核细胞的各种参数与心血管疾病相关。这些包括单核细胞计数、粘附特性增加、脂质代谢改变、LDL的吞噬作用和内吞作用。寻找标记物，更好地适用于临床导致单核细胞群体异质性的鉴定。用于鉴定单核细胞亚群的最好研究的标志物之一是CD16。虽然关于各种单核细胞亚群的起源和组成没有共识，但CD16+单核细胞群的大小增加与动脉粥样硬化的相关性已得到充分证实。发现与心血管疾病相关的单核细胞的其他表面标志物是CD18。CD11b、CXCR1、CD36和STAB1。对原代人单核细胞进行的功能研究支持这些分子对心血管疾病发病机制的重要性。对单核细胞生物学的持续研究导致了显示出显著的临床应用潜力的前景标志物的鉴定。这些包括单核细胞对挑战的反应和线粒体DNA异质性水平的分析。进一步的研究涉及基因组，蛋白质组学和细胞生物学技术，辅以系统生物学方法的数据分析和计算机模拟，需要定义单核细胞的分子和功能参数，用作诊断工具或治疗靶点。(C)2012 Elsevier GmbH. All rights reserved.
Inflammation is an important pathogenic factor of cardiovascular diseases. Inflammatory processes induce the organism systemic changes that are sensed by the cells of innate immune system. These systemic changes include increased concentrations of soluble factors capable of activating monocytes in the blood circulation therefore monocytes represent highly attractive cell population for diagnostic use. To date various parameters of circulating monocytes were associated with cardiovascular diseases. These comprise monocyte count, increased adhesive properties, alteration of lipid metabolism, phagocytosis and endocytosis of LDL. Search for markers, better suitable for clinical use led to identification of monocyte population heterogeneity. One of the best studied markers for identification of monocyte subpopulation is CD16. Although there is no consensus regarding the origin and composition of various monocyte subpopulations, association of increased size of CD16+ monocyte population with atherosclerosis is well established. Further surface markers of monocytes found to be associated with cardiovascular diseases are CD18. CD11b, CXCR1, CD36 and STAB1. Functional studies performed on primary human monocytes support the importance of these molecules for the pathogenesis of cardiovascular diseases. Continuous research on monocyte biology leads to identification of perspective markers that show significant potential of clinical use. These include analysis of monocyte response to a challenge and level of mitochondrial DNA heteroplasmy. Further research involving genomic, proteomic and cell biology techniques supplemented with systems biology approaches for data analysis and computer simulations are required for defining molecular and functional parameters of monocytes to be used as a diagnostic tool or therapeutic target. (C) 2012 Elsevier GmbH. All rights reserved.