Enhanced alveolar macrophage Ia antigen expression after asbestos inhalation.
Enhanced alveolar macrophage Ia antigen expression after asbestos inhalation.
复制标题
吸入石棉后肺泡巨噬细胞 Ia 抗原表达增强。
作者：
D. Hartmann;M. Georgian;E. Kagan
石棉肺是一种以吸入石棉粉尘导致的胸膜和间质性肺纤维化为特征的疾病（1）。尽管该病的发病机制还不完全清楚，但免疫机制被怀疑在石棉介导的肺损伤中起重要作用。也有证据表明，肺泡巨噬细胞（AM）在这方面可能是关键的。作为早期研究的延伸，作者最近表明，闪石（青石棉）和蛇纹石（温石棉）石棉吸入与体外培养过程中白细胞介素1（IL 1）和白细胞介素2（IL 2）的抗原导向释放增强有关。由于IL-1活性是已知的主要组织相容性复合体的1区域的控制下，本研究进行评估青石棉和温石棉吸入对Ia抗原表达AM的影响。通过使用确定的大鼠模型，在早期白细胞介素研究的同时，在一组动物中研究了石棉吸入的长期影响。另一组大鼠也被研究，以监测石棉暴露的短期影响。结果表明，大鼠吸入闪石和蛇纹石石棉均与AM上Ia表达增强有关。«少
Asbestos is a disease characterized by pleural and interstitial pulmonary fibrosis resulting from the inhalation of asbestos dust (1). Although the pathogenesis of the disease is not fully understood, immunologic mechanisms are suspected to play an important role in asbestos-mediated lung injury. There is also evidence that alveolar macrophages (AM) may be pivotal in this regard. As an extension of earlier studies, the authors have recently shown that both amphibole (crocidolite) and serpentine (chrysotile) asbestos inhalation are associated with augmented antigen-directed release of interleukin 1 (IL 1) and interleukin 2 (IL 2) during in vitro culture. Because IL 1 activity is known to be under the control of the 1 region of the major histocompatibility complex, the present study was undertaken to assess the effects of crocidolite and chrysotile asbestos inhalation on Ia antigen expression by AM. By using a defined rat model the longer-term effects of asbestos inhalation were studied in one set of animals at a time contemporaneous with the earlier interleukin study. Another set of rats was also studied to monitor the shorter-term effects of asbestos exposure. The results indicate that both amphibole and serpentine asbestos inhalation in the rat are associated with enhanced Ia expressitivity onmore » AM.« less