Increases in Levels of Schistosome-Specific Immunoglobulin E and CD23+ B Cells in a Cohort of Kenyan Children Undergoing Repeated Treatment and Reinfection with Schistosoma mansoni
Increases in Levels of Schistosome-Specific Immunoglobulin E and CD23+ B Cells in a Cohort of Kenyan Children Undergoing Repeated Treatment and Reinfection with Schistosoma mansoni
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DOI：
10.1086/653828
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发表时间：
2010-08-15
影响因子：
6.4
通讯作者：
Colley, Daniel G.
中科院分区：
文献类型：
--
作者：
Black, Carla L.;Muok, Erick M. O.;Colley, Daniel G.
背景。血吸虫病流行地区的年龄流行曲线表明，人类从青春期早期开始就对再感染产生了部分免疫力。我们进行了一项为期 2 年的纵向研究，以确定感染曼氏血吸虫的儿童在接受吡喹酮治疗后是否会产生保护相关的免疫反应，以及这些免疫反应的发展是否会因再次感染后频繁治疗而加速。 方法。儿童（8-10 岁）每 4 个月接受一次曼氏链球菌检测，阳性时使用吡喹酮治疗（A 组；n=68），或在 2 年随访期结束时进行检测和治疗（B 组；n=49）。 结果。 A 组中在随访期间保持未感染的儿童的血吸虫特异性免疫球蛋白 E (IgE) 基线水平显着高于重复诊断曼氏血吸虫感染≥2 次的儿童。重复诊断曼氏血吸虫感染≥2次的儿童在随访过程中接受≥3次吡喹酮治疗后，抗血吸虫IgE和CD23(+)B细胞水平显着升高。在仅接受基线吡喹酮治疗的儿童中，这两个参数均未见增加。结论。 B 细胞激活和抗血吸虫 IgE 与儿童对曼氏血吸虫的耐药性相关，并且这些免疫学参数可以通过多轮感染和吡喹酮诱导的治疗来增加。
Background. Age prevalence curves for areas in which schistosomiasis is endemic suggest that humans develop partial immunity to reinfection beginning in early adolescence. We conducted a 2-year longitudinal study to determine whether children infected with Schistosoma mansoni develop protection-related immune responses after treatment with praziquantel and whether the development of these immune responses is accelerated by frequent treatment after reinfection.Methods. Children (8-10 years old) were tested for S. mansoni every 4 months and treated with praziquantel when positive (arm A; n=68) or were tested and treated at the end of the 2-year follow-up period (arm B; n=49).Results. Children in arm A who remained free of infection during follow-up had significantly higher baseline levels of schistosome-specific immunoglobulin E (IgE) than did children with >= 2 repeat diagnoses of S. mansoni infection. Children with >= 2 repeat diagnoses of S. mansoni infection had significantly increased levels of anti-schistosome IgE and CD23(+) B cells after receiving >= 3 praziquantel treatments over the course of follow-up. No increase in either parameter was seen in children who received only the baseline praziquantel treatment.Conclusions. B cell activation and anti-schistosome IgE are associated with resistance to S. mansoni in children, and these immunological parameters can be increased by multiple rounds of infections and praziquantel-induced cures.