INTAKE OF POTENTIALLY ANTICARCINOGENIC FLAVONOIDS AND THEIR DETERMINANTS IN ADULTS IN THE NETHERLANDS
INTAKE OF POTENTIALLY ANTICARCINOGENIC FLAVONOIDS AND THEIR DETERMINANTS IN ADULTS IN THE NETHERLANDS
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DOI：
10.1080/01635589309514267
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发表时间：
1993-01-01
影响因子：
2.9
通讯作者：
KROMHOUT, D
中科院分区：
文献类型：
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作者：
HERTOG, MGL;HOLLMAN, PCH;KROMHOUT, D
香精是天然存在于食物中的强抗氧化剂，可以抑制啮齿动物的致癌作用。目前还没有关于全人群类黄酮摄入量的准确数据。在这里，使用荷兰全国食品消费调查1987-1988年的数据，我们报告了潜在的抗癌黄酮类化合物槲皮素，山奈酚，杨梅素，芹菜素和木犀草素的摄入量在4,112名成年人。采用高效液相色谱法测定蔬菜、水果和饮料中的黄酮类化合物含量。在所有受试者中，所有黄酮类化合物的平均摄入量为23 mg/天。最重要的类黄酮是黄酮醇槲皮素（平均摄入量16毫克/天）。类黄酮最重要的来源是茶（占总摄入量的48%），洋葱（29%）和苹果（79%）。不同季节的黄嘌呤摄入量没有变化;它与总能量摄入量无关（r = 0.001），与维生素A（视黄醇当量，r = 0.14），膳食纤维（r = 0.21）和维生素C（r = 0.26）的摄入量仅弱相关。我们使用新的分析技术表明，过去类黄酮的摄入量被高估了五倍。然而，按毫克/天计算，抗氧化剂类黄酮的摄入量仍然超过了抗氧化剂β-胡萝卜素和维生素E。因此，类黄酮是人类饮食中抗氧化剂的重要来源。
Flavonoids are strong antioxidants that occur naturally in foods and can inhibit carcinogenesis in rodents. Accurate data on population-wide intakes of flavonoids are not available. Here, using data of the Dutch National Food Consumption Survey 1987-1988, we report the intake of the potentially anticarcinogenic flavonoids quercetin, kaempferol, myricetin, apigenin, and luteolin among 4,112 adults. The flavonoid content of vegetables, fruits, and beverages was determined by high-performance liquid chromatography. In all subjects, average intake of all flavonoids combined was 23 mg/day. The most important flavonoid was the flavonol quercetin (mean intake 16 mg/day). The most important sources of flavonoids were tea (48% of total intake), onions (29%), and apples (79%). Flavonoid intake did not vary between seasons; it was not correlated with total energy intake (r = 0.001), and it was only weakly correlated with the intake of vitamin A (retinol equivalents, r = 0.14), dietary fiber (r = 0.21), and vitamin C (r = 0.26). Our use of new analytic technology suggests that in the past flavonoid intake has been overestimated fivefold. However, on a milligram-per-day basis, the intake of the antioxidant flavonoids still exceeded that of the antioxidants beta-carotene and vitamin E. Thus flavonoids represent an important source of antioxidants in the human diet.