What's new in IUGR from the endocrinological point of view?
What's new in IUGR from the endocrinological point of view?
复制标题
DOI：
10.5114/pedm.2019.91547
复制
发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Szalecki, Mieczyslaw
中科院分区：
文献类型：
--
作者：
Korpysz, Alicja;Szalecki, Mieczyslaw
IUGR的遗传原因：IGF 2基因编码IGF 2的合成有助于胎儿的生长.母体基因PHLDA 2、GRB 10和胎盘ALS也在调节胎儿生长中发挥作用。CDKN 1C突变可导致IUGR。在SRS综合征中，除了11 p15和二体性7的表型突变外，HMAGA 2-PLAG 1-IGF 2基因的突变可能是原因。生长缺陷：在10%的IUGR伴生长缺陷的儿童中，描述了ACAN基因突变（聚集蛋白聚糖基因）。IUGR和青春期动态演变的儿童通过GH和GnRH类似物的联合治疗可以获得更好的最终生长。胰岛素抵抗：根据新的报告，观察到怀孕期间的氧化应激，IUGR儿童胎儿期的表观遗传调节，以及追赶生长期间外周和中枢的胰岛素抵抗。
Genetic causes of IUGR: The IGF 2 gene encoding IGF2 synthesis contributes to growth of the foetus. The maternal genes PHLDA2, GRB10, and placental ALS also play arole in the regulation of foetal growth. CDKN1C mutation can lead to IUGR. In SRS syndrome, apart from epimutation 11p15 and disomy 7, the cause may be amutation of HMAGA2-PLAG1-IGF2 genes. Growth deficiency: in 10% of children with IUGR with growth deficiency, ACAN gene mutation (aggrecan gene) was described. Children with IUGR and with dynamic evolution of puberty can achieve better final growth through combined therapy with GH and GnRH analogues. Insulin resistance: In light of new reports, oxidative stress during pregnancy, epigenetic regulation in the foetal period in children with IUGR, and insulin resistance both peripheral and central during catch up growth" are observed.