Specific Visual Subregions of TPJ Mediate Reorienting of Spatial Attention
Specific Visual Subregions of TPJ Mediate Reorienting of Spatial Attention
复制标题
DOI：
10.1093/cercor/bhx140
复制
发表时间：
2018-07-01
期刊：
影响因子：
3.7
通讯作者：
Carrasco, Marisa
中科院分区：
文献类型：
--
作者：
Dugue, Laura;Merriam, Elisha P.;Carrasco, Marisa
颞顶交界区（TPJ）与多种认知和社会功能有关，是注意力重定向的关键。注意力影响早期视觉处理。神经影像学研究处理这样的过程，迄今为止集中在纹状体和外纹区。在这里，我们调查是否注意定向或重定向调制活动在视觉驱动的TPJ子区域。对于每个观察者，我们确定了TPJ内的3个视觉反应亚区：2个双侧（vTPJ（ant）和vTPJ（post））和1个右侧（vTPJ（cent））。在这些子区域的皮质活动进行了测量，而观察员进行了2个选择的强迫选择方向辨别任务的功能磁共振成像。内隐空间内源性（自愿）或外源性（非自愿）的注意操纵使用中央或外围线索与任务，刺激和观察员不变。内源性和外源性的注意力增加活动无效提示试验在右vTPJ（后），只有内源性的注意力增加活动无效提示试验在左vTPJ（后）和右vTPJ（分），既不类型的注意调制右或左vTPJ（蚂蚁）。这些结果表明，vTPJ（post）和vTPJ（cent）介导了内隐注意对任务相关刺激的重定向，从而在视觉注意中发挥了关键作用。这些发现揭示了观察者的注意力被主动或非主动地导向一个给定位置后，大脑皮层的不同重定向反应。
The temporo-parietal junction (TPJ) has been associated with various cognitive and social functions, and is critical for attentional reorienting. Attention affects early visual processing. Neuroimaging studies dealing with such processes have thus far concentrated on striate and extrastriate areas. Here, we investigated whether attention orienting or reorienting modulate activity in visually driven TPJ subregions. For each observer we identified 3 visually responsive subregions within TPJ: 2 bilateral (vTPJ(ant) and vTPJ(post)) and 1 right lateralized (vTPJ(cent)). Cortical activity in these subregions was measured using fMRI while observers performed a 2-alternative forced-choice orientation discrimination task. Covert spatial endogenous (voluntary) or exogenous (involuntary) attention was manipulated using either a central or a peripheral cue with task, stimuli and observers constant. Both endogenous and exogenous attention increased activity for invalidly cued trials in right vTPJ(post); only endogenous attention increased activity for invalidly cued trials in left vTPJ(post) and in right vTPJ(cent); and neither type of attention modulated either right or left vTPJ(ant). These results demonstrate that vTPJ(post) and vTPJ(cent) mediate the reorientation of covert attention to task relevant stimuli, thus playing a critical role in visual attention. These findings reveal a differential reorienting cortical response after observers' attention has been oriented to a given location voluntarily or involuntarily.