Differential transport of DNA by a rectified Brownian motion device.
Differential transport of DNA by a rectified Brownian motion device.
复制标题
通过修正布朗运动装置进行 DNA 的差动运输。
DOI：
10.1002/(sici)1522-2683(20000101)21:1
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Rothberg,JM
中科院分区：
文献类型：
--
作者：
Hammond,RW;Bader,JS;Henck,SA;Deem,MW;McDermott,GA;Bustillo,JM;Rothberg,JM
An interdigitated electrode array (IDEA) device has been designed and used to transport DNA based on a Brownian ratchet mechanism. This migration is produced by the periodic formation of an asymmetric sawtooth electric field in the device. Oligonucleo tides of 25, 50, and 100 bases in length were tested using two different array geometries. DNA transport as a function of DNA size, electric field frequency, and array geometry is shown to be in qualitative agreement with theory. Such a device could provide for DNA separations over a broad size range, and can be readily scaled as a component in a microfabricated DNA analysis system.
